Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum

Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum

Jun Wang,* Xin Zhang,* Bihong Zhu, Pan Fu On the behalf of Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Taizhou First People’s Hospital, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pan FuDepar...

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Autores principales: Wang J, Zhang X, Zhu B, Fu P
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
clusterin
neurogranin
synaptic degeneration
alzheimer’s disease
mild cognitive impairment
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/182f6b8c7b8645b7acbc2466d27ce287
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spelling oai:doaj.org-article:182f6b8c7b8645b7acbc2466d27ce2872021-12-02T11:02:09ZAssociation of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum1178-2021https://doaj.org/article/182f6b8c7b8645b7acbc2466d27ce2872020-01-01T00:00:00Zhttps://www.dovepress.com/association-of-clusterin-levels-in-cerebrospinal-fluid-with-synaptic-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jun Wang,* Xin Zhang,* Bihong Zhu, Pan Fu On the behalf of Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Taizhou First People’s Hospital, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pan FuDepartment of Neurology, Taizhou First People’s Hospital, 218 Hengjie Road, Huangyan District, Taizhou City, Zhejiang Province, People’s Republic of ChinaEmail fp7154515@163.comPurpose: Although emerging evidence has suggested that clusterin is involved in the pathogenesis of Alzheimer’s disease (AD), the association of clusterin with synaptic degeneration in living human is unclear. In the present study, we aimed to examine the association of CSF clusterin levels with synaptic degeneration in individuals with different severities of cognitive impairment.Patients and Methods: In the present study, we compared levels of clusterin in CSF among individuals with normal cognition (NC), mild cognitive impairment (MCI), and AD. Further, linear regression models were performed to examine the association of CSF clusterin with neurogranin (NG, reflecting synaptic degeneration) with adjustment of several potential confounders.Results: We found that CSF clusterin levels were positively correlated with NG in the NC and MCI groups, but not the AD group. In all subjects, linear regression models suggested that clusterin levels were positively associated with NG levels independent of age, gender, apolipoprotein E4 (APOE4) genotype, clinical diagnosis, and CSF Aβ 42 levels.Conclusion: Our data indicated that clusterin was associated with CSF NG levels among older individuals with different severities of cognitive impairment.Keywords: clusterin, neurogranin, synaptic degeneration, Alzheimer’s disease, mild cognitive impairmentWang JZhang XZhu BFu PDove Medical Pressarticleclusterinneurograninsynaptic degenerationalzheimer’s diseasemild cognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 183-190 (2020)
institution DOAJ
collection DOAJ
language EN
topic clusterin
neurogranin
synaptic degeneration
alzheimer’s disease
mild cognitive impairment
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle clusterin
neurogranin
synaptic degeneration
alzheimer’s disease
mild cognitive impairment
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Wang J
Zhang X
Zhu B
Fu P
Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
description Jun Wang,* Xin Zhang,* Bihong Zhu, Pan Fu On the behalf of Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Taizhou First People’s Hospital, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pan FuDepartment of Neurology, Taizhou First People’s Hospital, 218 Hengjie Road, Huangyan District, Taizhou City, Zhejiang Province, People’s Republic of ChinaEmail fp7154515@163.comPurpose: Although emerging evidence has suggested that clusterin is involved in the pathogenesis of Alzheimer’s disease (AD), the association of clusterin with synaptic degeneration in living human is unclear. In the present study, we aimed to examine the association of CSF clusterin levels with synaptic degeneration in individuals with different severities of cognitive impairment.Patients and Methods: In the present study, we compared levels of clusterin in CSF among individuals with normal cognition (NC), mild cognitive impairment (MCI), and AD. Further, linear regression models were performed to examine the association of CSF clusterin with neurogranin (NG, reflecting synaptic degeneration) with adjustment of several potential confounders.Results: We found that CSF clusterin levels were positively correlated with NG in the NC and MCI groups, but not the AD group. In all subjects, linear regression models suggested that clusterin levels were positively associated with NG levels independent of age, gender, apolipoprotein E4 (APOE4) genotype, clinical diagnosis, and CSF Aβ 42 levels.Conclusion: Our data indicated that clusterin was associated with CSF NG levels among older individuals with different severities of cognitive impairment.Keywords: clusterin, neurogranin, synaptic degeneration, Alzheimer’s disease, mild cognitive impairment
format article
author Wang J
Zhang X
Zhu B
Fu P
author_facet Wang J
Zhang X
Zhu B
Fu P
author_sort Wang J
title Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
title_short Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
title_full Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
title_fullStr Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
title_full_unstemmed Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
title_sort association of clusterin levels in cerebrospinal fluid with synaptic degeneration across the alzheimer’s disease continuum
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/182f6b8c7b8645b7acbc2466d27ce287
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AT zhub associationofclusterinlevelsincerebrospinalfluidwithsynapticdegenerationacrossthealzheimerrsquosdiseasecontinuum
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