IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis

Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead...

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Autores principales:	Josephine Diony Nanda, Tzong-Shiann Ho, Rahmat Dani Satria, Ming-Kai Jhan, Yung-Ting Wang, Chiou-Feng Lin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/18302b0ad20a4d998e7b8283cfa41b20
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spelling	oai:doaj.org-article:18302b0ad20a4d998e7b8283cfa41b202021-11-29T00:55:56ZIL-18: The Forgotten Cytokine in Dengue Immunopathogenesis2314-715610.1155/2021/8214656https://doaj.org/article/18302b0ad20a4d998e7b8283cfa41b202021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8214656https://doaj.org/toc/2314-7156Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.Josephine Diony NandaTzong-Shiann HoRahmat Dani SatriaMing-Kai JhanYung-Ting WangChiou-Feng LinHindawi LimitedarticleImmunologic diseases. AllergyRC581-607ENJournal of Immunology Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
description	Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.
format	article
author	Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin
author_facet	Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin
author_sort	Josephine Diony Nanda
title	IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
title_short	IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
title_full	IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
title_fullStr	IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
title_full_unstemmed	IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
title_sort	il-18: the forgotten cytokine in dengue immunopathogenesis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/18302b0ad20a4d998e7b8283cfa41b20
work_keys_str_mv	AT josephinedionynanda il18theforgottencytokineindengueimmunopathogenesis AT tzongshiannho il18theforgottencytokineindengueimmunopathogenesis AT rahmatdanisatria il18theforgottencytokineindengueimmunopathogenesis AT mingkaijhan il18theforgottencytokineindengueimmunopathogenesis AT yungtingwang il18theforgottencytokineindengueimmunopathogenesis AT chioufenglin il18theforgottencytokineindengueimmunopathogenesis
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IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis

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