Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study

Abstract We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese”...

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Autores principales:	Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1830a3c78ca74d72970b8d1a6437cc76
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spelling	oai:doaj.org-article:1830a3c78ca74d72970b8d1a6437cc762021-12-02T17:32:58ZObesity, metabolic health, and urological disorders in adults: a nationwide population-based study10.1038/s41598-021-88165-z2045-2322https://doaj.org/article/1830a3c78ca74d72970b8d1a6437cc762021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88165-zhttps://doaj.org/toc/2045-2322Abstract We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese” (O) or “non-obese” (NO) using a BMI cut-off of 25 kg/m2. People who developed ≥ 1 metabolic disease component in the index year were considered “metabolically unhealthy” (MU), while those with none were considered “metabolically healthy” (MH). There were classified into the MHNO, MUNO, MHO, and MUO group. In BPH, chronic renal disease, neurogenic bladder, any medication related to voiding dysfunction, alpha-blocker, and antidiuretics, age and gender-adjusted hazard ratio (HR) was highest in MUO, but higher in MUNO than in MHO. In stress incontinence, prostate surgery, and 5alpha-reductase, HR increased in the order of MUNO, MHO, and MUO. In prostatitis, anti-incontinence surgery, and cystocele repair, HR was higher in MHO than MUNO and MUO. In cystitis, cystostomy, and anticholinergics, HR was higher in MUNO and MUO than MHO. In conclusion, obesity and metabolic health were individually or collaboratively involved in urological disorders related to voiding dysfunction. Metabolic healthy obesity needs to be distinguished in the diagnosis and treatment of urological disorders.Jong Keun KimYoung Goo LeeKyungdo HanJun Hyun HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Keun Kim Young Goo Lee Kyungdo Han Jun Hyun Han Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
description	Abstract We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese” (O) or “non-obese” (NO) using a BMI cut-off of 25 kg/m2. People who developed ≥ 1 metabolic disease component in the index year were considered “metabolically unhealthy” (MU), while those with none were considered “metabolically healthy” (MH). There were classified into the MHNO, MUNO, MHO, and MUO group. In BPH, chronic renal disease, neurogenic bladder, any medication related to voiding dysfunction, alpha-blocker, and antidiuretics, age and gender-adjusted hazard ratio (HR) was highest in MUO, but higher in MUNO than in MHO. In stress incontinence, prostate surgery, and 5alpha-reductase, HR increased in the order of MUNO, MHO, and MUO. In prostatitis, anti-incontinence surgery, and cystocele repair, HR was higher in MHO than MUNO and MUO. In cystitis, cystostomy, and anticholinergics, HR was higher in MUNO and MUO than MHO. In conclusion, obesity and metabolic health were individually or collaboratively involved in urological disorders related to voiding dysfunction. Metabolic healthy obesity needs to be distinguished in the diagnosis and treatment of urological disorders.
format	article
author	Jong Keun Kim Young Goo Lee Kyungdo Han Jun Hyun Han
author_facet	Jong Keun Kim Young Goo Lee Kyungdo Han Jun Hyun Han
author_sort	Jong Keun Kim
title	Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_short	Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_full	Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_fullStr	Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_full_unstemmed	Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_sort	obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1830a3c78ca74d72970b8d1a6437cc76
work_keys_str_mv	AT jongkeunkim obesitymetabolichealthandurologicaldisordersinadultsanationwidepopulationbasedstudy AT younggoolee obesitymetabolichealthandurologicaldisordersinadultsanationwidepopulationbasedstudy AT kyungdohan obesitymetabolichealthandurologicaldisordersinadultsanationwidepopulationbasedstudy AT junhyunhan obesitymetabolichealthandurologicaldisordersinadultsanationwidepopulationbasedstudy
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Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study

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