Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms i...

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Autores principales:	Fabio A. Iannotti, Ester Pagano, Ombretta Guardiola, Simone Adinolfi, Valentina Saccone, Silvia Consalvi, Fabiana Piscitelli, Elisabetta Gazzerro, Giuseppe Busetto, Diego Carrella, Raffaele Capasso, Pier Lorenzo Puri, Gabriella Minchiotti, Vincenzo Di Marzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18374656998d4f538355e4174ad2ce20
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spelling	oai:doaj.org-article:18374656998d4f538355e4174ad2ce202021-12-02T16:50:05ZGenetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy10.1038/s41467-018-06267-12041-1723https://doaj.org/article/18374656998d4f538355e4174ad2ce202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06267-1https://doaj.org/toc/2041-1723The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms in DMD mouse models.Fabio A. IannottiEster PaganoOmbretta GuardiolaSimone AdinolfiValentina SacconeSilvia ConsalviFabiana PiscitelliElisabetta GazzerroGiuseppe BusettoDiego CarrellaRaffaele CapassoPier Lorenzo PuriGabriella MinchiottiVincenzo Di MarzoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabio A. Iannotti Ester Pagano Ombretta Guardiola Simone Adinolfi Valentina Saccone Silvia Consalvi Fabiana Piscitelli Elisabetta Gazzerro Giuseppe Busetto Diego Carrella Raffaele Capasso Pier Lorenzo Puri Gabriella Minchiotti Vincenzo Di Marzo Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
description	The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms in DMD mouse models.
format	article
author	Fabio A. Iannotti Ester Pagano Ombretta Guardiola Simone Adinolfi Valentina Saccone Silvia Consalvi Fabiana Piscitelli Elisabetta Gazzerro Giuseppe Busetto Diego Carrella Raffaele Capasso Pier Lorenzo Puri Gabriella Minchiotti Vincenzo Di Marzo
author_facet	Fabio A. Iannotti Ester Pagano Ombretta Guardiola Simone Adinolfi Valentina Saccone Silvia Consalvi Fabiana Piscitelli Elisabetta Gazzerro Giuseppe Busetto Diego Carrella Raffaele Capasso Pier Lorenzo Puri Gabriella Minchiotti Vincenzo Di Marzo
author_sort	Fabio A. Iannotti
title	Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
title_short	Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
title_full	Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
title_fullStr	Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
title_full_unstemmed	Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
title_sort	genetic and pharmacological regulation of the endocannabinoid cb1 receptor in duchenne muscular dystrophy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/18374656998d4f538355e4174ad2ce20
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Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

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