Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy

The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and metastasis. CSCs show intrinsic resistance to conventional therapies and phenotypic plasticity within the tumor, which make these a difficult target for conventional therapies. CSCs have different meta...

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Autores principales:	Jasmeet Kaur, Shalmoli Bhattacharyya
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolism cancer stem cell glucose glutamine OxPhos Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/18421b6d985740189fd642151537dec3
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id	oai:doaj.org-article:18421b6d985740189fd642151537dec3
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spelling	oai:doaj.org-article:18421b6d985740189fd642151537dec32021-11-05T11:41:45ZCancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy2234-943X10.3389/fonc.2021.756888https://doaj.org/article/18421b6d985740189fd642151537dec32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.756888/fullhttps://doaj.org/toc/2234-943XThe subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and metastasis. CSCs show intrinsic resistance to conventional therapies and phenotypic plasticity within the tumor, which make these a difficult target for conventional therapies. CSCs have different metabolic phenotypes based on their needs as compared to the bulk cancer cells. CSCs show metabolic plasticity and constantly alter their metabolic state between glycolysis and oxidative metabolism (OXPHOS) to adapt to scarcity of nutrients and therapeutic stress. The metabolic characteristics of CSCs are distinct compared to non-CSCs and thus provide an opportunity to devise more effective strategies to target CSCs. Mechanism for metabolic switch in CSCs is still unravelled, however existing evidence suggests that tumor microenvironment affects the metabolic phenotype of cancer cells. Understanding CSCs metabolism may help in discovering new and effective clinical targets to prevent cancer relapse and metastasis. This review summarises the current knowledge of CSCs metabolism and highlights the potential targeted treatment strategies.Jasmeet KaurShalmoli BhattacharyyaFrontiers Media S.A.articlemetabolismcancer stem cellglucoseglutamineOxPhosNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolism cancer stem cell glucose glutamine OxPhos Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	metabolism cancer stem cell glucose glutamine OxPhos Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jasmeet Kaur Shalmoli Bhattacharyya Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
description	The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor recurrence and metastasis. CSCs show intrinsic resistance to conventional therapies and phenotypic plasticity within the tumor, which make these a difficult target for conventional therapies. CSCs have different metabolic phenotypes based on their needs as compared to the bulk cancer cells. CSCs show metabolic plasticity and constantly alter their metabolic state between glycolysis and oxidative metabolism (OXPHOS) to adapt to scarcity of nutrients and therapeutic stress. The metabolic characteristics of CSCs are distinct compared to non-CSCs and thus provide an opportunity to devise more effective strategies to target CSCs. Mechanism for metabolic switch in CSCs is still unravelled, however existing evidence suggests that tumor microenvironment affects the metabolic phenotype of cancer cells. Understanding CSCs metabolism may help in discovering new and effective clinical targets to prevent cancer relapse and metastasis. This review summarises the current knowledge of CSCs metabolism and highlights the potential targeted treatment strategies.
format	article
author	Jasmeet Kaur Shalmoli Bhattacharyya
author_facet	Jasmeet Kaur Shalmoli Bhattacharyya
author_sort	Jasmeet Kaur
title	Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
title_short	Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
title_full	Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
title_fullStr	Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
title_full_unstemmed	Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
title_sort	cancer stem cells: metabolic characterization for targeted cancer therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/18421b6d985740189fd642151537dec3
work_keys_str_mv	AT jasmeetkaur cancerstemcellsmetaboliccharacterizationfortargetedcancertherapy AT shalmolibhattacharyya cancerstemcellsmetaboliccharacterizationfortargetedcancertherapy
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Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy

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