A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions

A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions

The interrogation of noncoding regions of the genome with CRISPR strategies requires dense and, ideally, inexpensive libraries to ensure coverage and customisation. Here the authors present 'Molecular Chipper' that uses fragmentation to generate guide RNAs from input DNA.

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Autores principales: Jijun Cheng, Christine A. Roden, Wen Pan, Shu Zhu, Anna Baccei, Xinghua Pan, Tingting Jiang, Yuval Kluger, Sherman M. Weissman, Shangqin Guo, Richard A. Flavell, Ye Ding, Jun Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/18430b661da84ddb83ebbefbef3dc891
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