Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

<h4>Background</h4>Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an eff...

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Autores principales: Amy V Pointon, Tracy M Walker, Kate M Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D Parry, Jonathan J Lyon, Emma L Marczylo, Timothy W Gant
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/184c284d03e04d15969cfbb2005712c1
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