Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus

Abstract CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of soluble CD226 (sCD226) in SLE is still unknown. In the present study, we measured...

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Autores principales:	Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/184c7d5b436a488e8be4ca2c72aa394a
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spelling	oai:doaj.org-article:184c7d5b436a488e8be4ca2c72aa394a2021-12-02T15:08:39ZAssociation of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus10.1038/s41598-021-95711-22045-2322https://doaj.org/article/184c7d5b436a488e8be4ca2c72aa394a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95711-2https://doaj.org/toc/2045-2322Abstract CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of soluble CD226 (sCD226) in SLE is still unknown. In the present study, we measured serum sCD226 levels using an enzyme-linked immunosorbent assay in 58 SLE patients and 33 healthy controls (HCs) and evaluated their associations with SLE Disease Activity Index 2000 (SLEDAI-2K), clinical manifestations, laboratory data, and the cumulative probability of flare. Serum sCD226 levels showed no significant differences between SLE patients and HCs. However, sCD226 levels were significantly elevated in active SLE patients with a SLEDAI-2K score of ≥ 20 compared with HCs. In SLE patients, sCD226 levels were significantly correlated with SLEDAI-2K scores and anti-dsDNA antibody titers. Moreover, the cumulative probability of flare was markedly higher in patients with high sCD226 than in those with low sCD226. In patients with neuropsychiatric involvement, sCD226 levels were elevated and reflected neuropsychiatric disease activity. These findings indicate that serum sCD226 levels are associated with disease activity and flares of SLE. Thus, it may be a useful biomarker for SLE, and its monitoring allows for more precise SLE management.Miki NakanoMasahiro AyanoKazuo KushimotoShotaro KawanoKazuhiko HigashiokaShoichiro InokuchiHiroki MitomaYasutaka KimotoMitsuteru AkahoshiNobuyuki OnoYojiro ArinobuKoichi AkashiTakahiko HoriuchiHiroaki NiiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miki Nakano Masahiro Ayano Kazuo Kushimoto Shotaro Kawano Kazuhiko Higashioka Shoichiro Inokuchi Hiroki Mitoma Yasutaka Kimoto Mitsuteru Akahoshi Nobuyuki Ono Yojiro Arinobu Koichi Akashi Takahiko Horiuchi Hiroaki Niiro Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
description	Abstract CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of soluble CD226 (sCD226) in SLE is still unknown. In the present study, we measured serum sCD226 levels using an enzyme-linked immunosorbent assay in 58 SLE patients and 33 healthy controls (HCs) and evaluated their associations with SLE Disease Activity Index 2000 (SLEDAI-2K), clinical manifestations, laboratory data, and the cumulative probability of flare. Serum sCD226 levels showed no significant differences between SLE patients and HCs. However, sCD226 levels were significantly elevated in active SLE patients with a SLEDAI-2K score of ≥ 20 compared with HCs. In SLE patients, sCD226 levels were significantly correlated with SLEDAI-2K scores and anti-dsDNA antibody titers. Moreover, the cumulative probability of flare was markedly higher in patients with high sCD226 than in those with low sCD226. In patients with neuropsychiatric involvement, sCD226 levels were elevated and reflected neuropsychiatric disease activity. These findings indicate that serum sCD226 levels are associated with disease activity and flares of SLE. Thus, it may be a useful biomarker for SLE, and its monitoring allows for more precise SLE management.
format	article
author	Miki Nakano Masahiro Ayano Kazuo Kushimoto Shotaro Kawano Kazuhiko Higashioka Shoichiro Inokuchi Hiroki Mitoma Yasutaka Kimoto Mitsuteru Akahoshi Nobuyuki Ono Yojiro Arinobu Koichi Akashi Takahiko Horiuchi Hiroaki Niiro
author_facet	Miki Nakano Masahiro Ayano Kazuo Kushimoto Shotaro Kawano Kazuhiko Higashioka Shoichiro Inokuchi Hiroki Mitoma Yasutaka Kimoto Mitsuteru Akahoshi Nobuyuki Ono Yojiro Arinobu Koichi Akashi Takahiko Horiuchi Hiroaki Niiro
author_sort	Miki Nakano
title	Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
title_short	Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
title_full	Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
title_fullStr	Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
title_full_unstemmed	Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
title_sort	association of elevated serum soluble cd226 levels with the disease activity and flares of systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/184c7d5b436a488e8be4ca2c72aa394a
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Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus

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