General health of patients with diabetic macular edema-The LIPSIA study.
<h4>Purpose</h4>Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.<h4>Methods</h4...
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oai:doaj.org-article:1850d8b8b37f4376962f4dd0757727ef2021-11-25T06:23:33ZGeneral health of patients with diabetic macular edema-The LIPSIA study.1932-620310.1371/journal.pone.0252321https://doaj.org/article/1850d8b8b37f4376962f4dd0757727ef2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252321https://doaj.org/toc/1932-6203<h4>Purpose</h4>Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.<h4>Methods</h4>Prospective, monocentric observational study. Patients presenting for the treatment of DME received laboratory and clinical examinations including 24-hour blood pressure measurement.<h4>Results</h4>Seventy-five consecutive patients were included in the study. The mean age was 61.0 ± 14.5 years, and 83% had type 2 diabetes. The mean body mass index (BMI) was 32.8 ± 6.0 kg/m2. Overweight (BMI ≥ 25 kg/m2) was present in 92% of all patients. HbA1c values were > 7.0% in 57%. Although 87% of the patients already received antihypertensive therapy, the blood pressure (BP) of 82% was still above the recommended target values of systolic < 140 mmHg and diastolic < 80 mmHg. An insufficient nocturnal fall of the systolic BP (< 10%, non-dipping or reverse dipping) was observed in 62%. In 83% of the patients the glomerular filtration rate was ≤ 90 ml/min/1.73m2. Despite 65% of the cohort already receiving lipid-lowering therapy, LDL cholesterol was above the target value of 1.4 mmol/l in 93%. All patients had at least one cardiovascular risk factor in addition to diabetes (overweight, hypertension, insufficient nocturnal BP fall, dyslipidemia, or renal dysfunction) and 86% had ≥ 3 risk factors.<h4>Conclusion</h4>DME patients are characterized by highly prevalent cardiovascular risk factors that are poorly controlled. These comorbidities reduce the prognosis and negatively influence existing DR and DME. The data reveal an important opportunity for improving patient care by interaction of the ophthalmologist with the general practitioner and internal specialists for the detection and treatment of these conditions.Catharina BuschJulius L KatzmannClaudia JochmannJan Darius UnterlauftDaniela VollhardtPeter WiedemannUlrich LaufsMatus RehakPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252321 (2021) |
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| collection |
DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Catharina Busch Julius L Katzmann Claudia Jochmann Jan Darius Unterlauft Daniela Vollhardt Peter Wiedemann Ulrich Laufs Matus Rehak General health of patients with diabetic macular edema-The LIPSIA study. |
| description |
<h4>Purpose</h4>Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.<h4>Methods</h4>Prospective, monocentric observational study. Patients presenting for the treatment of DME received laboratory and clinical examinations including 24-hour blood pressure measurement.<h4>Results</h4>Seventy-five consecutive patients were included in the study. The mean age was 61.0 ± 14.5 years, and 83% had type 2 diabetes. The mean body mass index (BMI) was 32.8 ± 6.0 kg/m2. Overweight (BMI ≥ 25 kg/m2) was present in 92% of all patients. HbA1c values were > 7.0% in 57%. Although 87% of the patients already received antihypertensive therapy, the blood pressure (BP) of 82% was still above the recommended target values of systolic < 140 mmHg and diastolic < 80 mmHg. An insufficient nocturnal fall of the systolic BP (< 10%, non-dipping or reverse dipping) was observed in 62%. In 83% of the patients the glomerular filtration rate was ≤ 90 ml/min/1.73m2. Despite 65% of the cohort already receiving lipid-lowering therapy, LDL cholesterol was above the target value of 1.4 mmol/l in 93%. All patients had at least one cardiovascular risk factor in addition to diabetes (overweight, hypertension, insufficient nocturnal BP fall, dyslipidemia, or renal dysfunction) and 86% had ≥ 3 risk factors.<h4>Conclusion</h4>DME patients are characterized by highly prevalent cardiovascular risk factors that are poorly controlled. These comorbidities reduce the prognosis and negatively influence existing DR and DME. The data reveal an important opportunity for improving patient care by interaction of the ophthalmologist with the general practitioner and internal specialists for the detection and treatment of these conditions. |
| format |
article |
| author |
Catharina Busch Julius L Katzmann Claudia Jochmann Jan Darius Unterlauft Daniela Vollhardt Peter Wiedemann Ulrich Laufs Matus Rehak |
| author_facet |
Catharina Busch Julius L Katzmann Claudia Jochmann Jan Darius Unterlauft Daniela Vollhardt Peter Wiedemann Ulrich Laufs Matus Rehak |
| author_sort |
Catharina Busch |
| title |
General health of patients with diabetic macular edema-The LIPSIA study. |
| title_short |
General health of patients with diabetic macular edema-The LIPSIA study. |
| title_full |
General health of patients with diabetic macular edema-The LIPSIA study. |
| title_fullStr |
General health of patients with diabetic macular edema-The LIPSIA study. |
| title_full_unstemmed |
General health of patients with diabetic macular edema-The LIPSIA study. |
| title_sort |
general health of patients with diabetic macular edema-the lipsia study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/1850d8b8b37f4376962f4dd0757727ef |
| work_keys_str_mv |
AT catharinabusch generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT juliuslkatzmann generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT claudiajochmann generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT jandariusunterlauft generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT danielavollhardt generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT peterwiedemann generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT ulrichlaufs generalhealthofpatientswithdiabeticmacularedemathelipsiastudy AT matusrehak generalhealthofpatientswithdiabeticmacularedemathelipsiastudy |
| _version_ |
1718413788253782016 |