High information capacity DNA-based data storage with augmented encoding characters using degenerate bases

Abstract DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose t...

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Autores principales:	Yeongjae Choi, Taehoon Ryu, Amos C. Lee, Hansol Choi, Hansaem Lee, Jaejun Park, Suk-Heung Song, Seojoo Kim, Hyeli Kim, Wook Park, Sunghoon Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1850e94c43934ed380bb8abe924a3e09
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spelling	oai:doaj.org-article:1850e94c43934ed380bb8abe924a3e092021-12-02T15:09:54ZHigh information capacity DNA-based data storage with augmented encoding characters using degenerate bases10.1038/s41598-019-43105-w2045-2322https://doaj.org/article/1850e94c43934ed380bb8abe924a3e092019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-43105-whttps://doaj.org/toc/2045-2322Abstract DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases as encoding characters in addition to A, C, G, and T, which augments the amount of data that can be stored per length of DNA sequence designed (information capacity) and lowering the amount of DNA synthesis per storing unit data. Using the proposed method, we experimentally achieved an information capacity of 3.37 bits/character. The demonstrated information capacity is more than twice when compared to the highest information capacity previously achieved. The proposed method can be integrated with synthetic technologies in the future to reduce the cost of DNA-based data storage by 50%.Yeongjae ChoiTaehoon RyuAmos C. LeeHansol ChoiHansaem LeeJaejun ParkSuk-Heung SongSeojoo KimHyeli KimWook ParkSunghoon KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeongjae Choi Taehoon Ryu Amos C. Lee Hansol Choi Hansaem Lee Jaejun Park Suk-Heung Song Seojoo Kim Hyeli Kim Wook Park Sunghoon Kwon High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
description	Abstract DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases as encoding characters in addition to A, C, G, and T, which augments the amount of data that can be stored per length of DNA sequence designed (information capacity) and lowering the amount of DNA synthesis per storing unit data. Using the proposed method, we experimentally achieved an information capacity of 3.37 bits/character. The demonstrated information capacity is more than twice when compared to the highest information capacity previously achieved. The proposed method can be integrated with synthetic technologies in the future to reduce the cost of DNA-based data storage by 50%.
format	article
author	Yeongjae Choi Taehoon Ryu Amos C. Lee Hansol Choi Hansaem Lee Jaejun Park Suk-Heung Song Seojoo Kim Hyeli Kim Wook Park Sunghoon Kwon
author_facet	Yeongjae Choi Taehoon Ryu Amos C. Lee Hansol Choi Hansaem Lee Jaejun Park Suk-Heung Song Seojoo Kim Hyeli Kim Wook Park Sunghoon Kwon
author_sort	Yeongjae Choi
title	High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
title_short	High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
title_full	High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
title_fullStr	High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
title_full_unstemmed	High information capacity DNA-based data storage with augmented encoding characters using degenerate bases
title_sort	high information capacity dna-based data storage with augmented encoding characters using degenerate bases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1850e94c43934ed380bb8abe924a3e09
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High information capacity DNA-based data storage with augmented encoding characters using degenerate bases

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