Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

ABSTRACT Inflammatory responses, while essential for pathogen clearance, can also be deleterious to the host. Chemical inhibition of topoisomerase 1 (Top1) by low-dose camptothecin (CPT) can suppress transcriptional induction of antiviral and inflammatory genes and protect animals from excessive and...

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Bibliographic Details
Main Authors: Geneviève Pépin, Charlotte Nejad, Jonathan Ferrand, Belinda J. Thomas, H. James Stunden, Elaine Sanij, Chwan-Hong Foo, Cameron R. Stewart, Jason E. Cain, Philip G. Bardin, Bryan R. G. Williams, Michael P. Gantier
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
DNA damage
STING
cGAS
camptothecin
simian virus 40
topoisomerase 1
Microbiology
QR1-502
Online Access:https://doaj.org/article/1854a7e1960c44029afa2f6f6b8c9dcb
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