Human papillomavirus 16 E5 modulates the expression of host microRNAs.

Human papillomavirus 16 E5 modulates the expression of host microRNAs.

Human papillomavirus (HPV) infection is a prerequisite of developing cervical cancer, approximately half of which are associated with HPV type 16. HPV 16 encodes three oncogenes, E5, E6, and E7, of which E5 is the least studied so far. Its roles in regulating replication and pathogenesis of HPV are...

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Autores principales: Dario Greco, Niina Kivi, Kui Qian, Suvi-Katri Leivonen, Petri Auvinen, Eeva Auvinen
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/185a59bc598c403d9822c01d03ee3128
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spelling oai:doaj.org-article:185a59bc598c403d9822c01d03ee31282021-11-18T06:50:49ZHuman papillomavirus 16 E5 modulates the expression of host microRNAs.1932-620310.1371/journal.pone.0021646https://doaj.org/article/185a59bc598c403d9822c01d03ee31282011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21747943/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Human papillomavirus (HPV) infection is a prerequisite of developing cervical cancer, approximately half of which are associated with HPV type 16. HPV 16 encodes three oncogenes, E5, E6, and E7, of which E5 is the least studied so far. Its roles in regulating replication and pathogenesis of HPV are not fully understood. Here we utilize high-throughput screening to coordinately investigate the effect of E5 on the expression of host protein-coding and microRNA genes. MicroRNAs form a class of 22nt long noncoding RNAs with regulatory activity. Among the altered cellular microRNAs we focus on the alteration in the expression of miR-146a, miR-203 and miR-324-5p and their target genes in a time interval of 96 hours of E5 induction. Our results indicate that HPV infection and subsequent transformation take place through complex regulatory patterns of gene expression in the host cells, part of which are regulated by the E5 protein.Dario GrecoNiina KiviKui QianSuvi-Katri LeivonenPetri AuvinenEeva AuvinenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21646 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Dario Greco
Niina Kivi
Kui Qian
Suvi-Katri Leivonen
Petri Auvinen
Eeva Auvinen
Human papillomavirus 16 E5 modulates the expression of host microRNAs.
description Human papillomavirus (HPV) infection is a prerequisite of developing cervical cancer, approximately half of which are associated with HPV type 16. HPV 16 encodes three oncogenes, E5, E6, and E7, of which E5 is the least studied so far. Its roles in regulating replication and pathogenesis of HPV are not fully understood. Here we utilize high-throughput screening to coordinately investigate the effect of E5 on the expression of host protein-coding and microRNA genes. MicroRNAs form a class of 22nt long noncoding RNAs with regulatory activity. Among the altered cellular microRNAs we focus on the alteration in the expression of miR-146a, miR-203 and miR-324-5p and their target genes in a time interval of 96 hours of E5 induction. Our results indicate that HPV infection and subsequent transformation take place through complex regulatory patterns of gene expression in the host cells, part of which are regulated by the E5 protein.
format article
author Dario Greco
Niina Kivi
Kui Qian
Suvi-Katri Leivonen
Petri Auvinen
Eeva Auvinen
author_facet Dario Greco
Niina Kivi
Kui Qian
Suvi-Katri Leivonen
Petri Auvinen
Eeva Auvinen
author_sort Dario Greco
title Human papillomavirus 16 E5 modulates the expression of host microRNAs.
title_short Human papillomavirus 16 E5 modulates the expression of host microRNAs.
title_full Human papillomavirus 16 E5 modulates the expression of host microRNAs.
title_fullStr Human papillomavirus 16 E5 modulates the expression of host microRNAs.
title_full_unstemmed Human papillomavirus 16 E5 modulates the expression of host microRNAs.
title_sort human papillomavirus 16 e5 modulates the expression of host micrornas.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/185a59bc598c403d9822c01d03ee3128
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