Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.

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Autores principales:	Darci Phillips, Magdalena Matusiak, Belén Rivero Gutierrez, Salil S. Bhate, Graham L. Barlow, Sizun Jiang, Janos Demeter, Kimberly S. Smythe, Robert H. Pierce, Steven P. Fling, Nirasha Ramchurren, Martin A. Cheever, Yury Goltsev, Robert B. West, Michael S. Khodadoust, Youn H. Kim, Christian M. Schürch, Garry P. Nolan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/185b95b3ae0241efb2f75ef0ed8fba8c
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spelling	oai:doaj.org-article:185b95b3ae0241efb2f75ef0ed8fba8c2021-11-21T12:34:17ZImmune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma10.1038/s41467-021-26974-62041-1723https://doaj.org/article/185b95b3ae0241efb2f75ef0ed8fba8c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26974-6https://doaj.org/toc/2041-1723PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.Darci PhillipsMagdalena MatusiakBelén Rivero GutierrezSalil S. BhateGraham L. BarlowSizun JiangJanos DemeterKimberly S. SmytheRobert H. PierceSteven P. FlingNirasha RamchurrenMartin A. CheeverYury GoltsevRobert B. WestMichael S. KhodadoustYoun H. KimChristian M. SchürchGarry P. NolanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Darci Phillips Magdalena Matusiak Belén Rivero Gutierrez Salil S. Bhate Graham L. Barlow Sizun Jiang Janos Demeter Kimberly S. Smythe Robert H. Pierce Steven P. Fling Nirasha Ramchurren Martin A. Cheever Yury Goltsev Robert B. West Michael S. Khodadoust Youn H. Kim Christian M. Schürch Garry P. Nolan Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
description	PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.
format	article
author	Darci Phillips Magdalena Matusiak Belén Rivero Gutierrez Salil S. Bhate Graham L. Barlow Sizun Jiang Janos Demeter Kimberly S. Smythe Robert H. Pierce Steven P. Fling Nirasha Ramchurren Martin A. Cheever Yury Goltsev Robert B. West Michael S. Khodadoust Youn H. Kim Christian M. Schürch Garry P. Nolan
author_facet	Darci Phillips Magdalena Matusiak Belén Rivero Gutierrez Salil S. Bhate Graham L. Barlow Sizun Jiang Janos Demeter Kimberly S. Smythe Robert H. Pierce Steven P. Fling Nirasha Ramchurren Martin A. Cheever Yury Goltsev Robert B. West Michael S. Khodadoust Youn H. Kim Christian M. Schürch Garry P. Nolan
author_sort	Darci Phillips
title	Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
title_short	Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
title_full	Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
title_fullStr	Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
title_full_unstemmed	Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
title_sort	immune cell topography predicts response to pd-1 blockade in cutaneous t cell lymphoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/185b95b3ae0241efb2f75ef0ed8fba8c
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Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

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