Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

Hanie Yavarpour-Bali,1 Maryam Ghasemi-Kasman,2,3 Marzieh Pirzadeh11Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 3Neuroscience Research Cent...

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Autores principales:	Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Curcumin Central nervous system diseases Nanoparticles Water Solubility Bioavailability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/185dafb4455f4b7c8559400137a4ec05
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spelling	oai:doaj.org-article:185dafb4455f4b7c8559400137a4ec052021-12-02T07:43:24ZCurcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders1178-2013https://doaj.org/article/185dafb4455f4b7c8559400137a4ec052019-06-01T00:00:00Zhttps://www.dovepress.com/curcumin-loaded-nanoparticles-a-novel-therapeutic-strategy-in-treatmen-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hanie Yavarpour-Bali,1 Maryam Ghasemi-Kasman,2,3 Marzieh Pirzadeh11Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 3Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranAbstract: Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson’s disease, Huntington disease, Alzheimer’s disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.Keywords: curcumin, central nervous system diseases, nanoparticles, water solubility, bioavailabilityYavarpour-Bali HGhasemi-Kasman MPirzadeh MDove Medical PressarticleCurcuminCentral nervous system diseasesNanoparticlesWater SolubilityBioavailabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4449-4460 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Curcumin Central nervous system diseases Nanoparticles Water Solubility Bioavailability Medicine (General) R5-920
spellingShingle	Curcumin Central nervous system diseases Nanoparticles Water Solubility Bioavailability Medicine (General) R5-920 Yavarpour-Bali H Ghasemi-Kasman M Pirzadeh M Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
description	Hanie Yavarpour-Bali,1 Maryam Ghasemi-Kasman,2,3 Marzieh Pirzadeh11Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 3Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranAbstract: Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson’s disease, Huntington disease, Alzheimer’s disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.Keywords: curcumin, central nervous system diseases, nanoparticles, water solubility, bioavailability
format	article
author	Yavarpour-Bali H Ghasemi-Kasman M Pirzadeh M
author_facet	Yavarpour-Bali H Ghasemi-Kasman M Pirzadeh M
author_sort	Yavarpour-Bali H
title	Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
title_short	Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
title_full	Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
title_fullStr	Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
title_full_unstemmed	Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
title_sort	curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/185dafb4455f4b7c8559400137a4ec05
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Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

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