Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.

<h4>Objectives</h4>Inflammation is involved in the pathogenesis of depression. A few cross-sectional population-based studies have found that depression is associated with increased levels of inflammatory markers. Soluble urokinase plasminogen activation receptor (suPAR) is known to be a...

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Autores principales:	Eva Haastrup, Katrine Grau, Jesper Eugen-Olsen, Christian Thorball, Lars Vedel Kessing, Henrik Ullum
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18601855b7964800aa51a051d0b182a9
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spelling	oai:doaj.org-article:18601855b7964800aa51a051d0b182a92021-11-25T05:56:00ZSoluble urokinase plasminogen activator receptor as a marker for use of antidepressants.1932-620310.1371/journal.pone.0110555https://doaj.org/article/18601855b7964800aa51a051d0b182a92014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110555https://doaj.org/toc/1932-6203<h4>Objectives</h4>Inflammation is involved in the pathogenesis of depression. A few cross-sectional population-based studies have found that depression is associated with increased levels of inflammatory markers. Soluble urokinase plasminogen activation receptor (suPAR) is known to be a stable marker for inflammation. We investigated the bidirectional association between suPAR levels and use of antidepressants.<h4>Methods</h4>suPAR level was measured in 9305 blood donors and analysed in relation to 5-years follow-up data on purchase of antidepressants and hospital diagnoses of depression from a nationwide Danish register.<h4>Results</h4>For men and women without prior use of antidepressants we found a significantly higher risk for incident use of antidepressants with higher suPAR values. For men, the risk of first use of antidepressants increased by 72% from the 1st to the 4th quartile (HR = 1.72, 95% CI: 1.11-2.69). For women, it increased by 108% from the 1st to the 4th quartile (HR = 2.08, 95% CI: 1.45-2.98). Previous use of antidepressants was also significantly associated with higher suPAR levels (p = 0.002).<h4>Conclusions</h4>High suPAR levels are associated with an increased risk for both previous and future use of antidepressants in healthy men and women. High suPAR are also associated with increased risk for a hospital diagnosis of depression.Eva HaastrupKatrine GrauJesper Eugen-OlsenChristian ThorballLars Vedel KessingHenrik UllumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110555 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Haastrup Katrine Grau Jesper Eugen-Olsen Christian Thorball Lars Vedel Kessing Henrik Ullum Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
description	<h4>Objectives</h4>Inflammation is involved in the pathogenesis of depression. A few cross-sectional population-based studies have found that depression is associated with increased levels of inflammatory markers. Soluble urokinase plasminogen activation receptor (suPAR) is known to be a stable marker for inflammation. We investigated the bidirectional association between suPAR levels and use of antidepressants.<h4>Methods</h4>suPAR level was measured in 9305 blood donors and analysed in relation to 5-years follow-up data on purchase of antidepressants and hospital diagnoses of depression from a nationwide Danish register.<h4>Results</h4>For men and women without prior use of antidepressants we found a significantly higher risk for incident use of antidepressants with higher suPAR values. For men, the risk of first use of antidepressants increased by 72% from the 1st to the 4th quartile (HR = 1.72, 95% CI: 1.11-2.69). For women, it increased by 108% from the 1st to the 4th quartile (HR = 2.08, 95% CI: 1.45-2.98). Previous use of antidepressants was also significantly associated with higher suPAR levels (p = 0.002).<h4>Conclusions</h4>High suPAR levels are associated with an increased risk for both previous and future use of antidepressants in healthy men and women. High suPAR are also associated with increased risk for a hospital diagnosis of depression.
format	article
author	Eva Haastrup Katrine Grau Jesper Eugen-Olsen Christian Thorball Lars Vedel Kessing Henrik Ullum
author_facet	Eva Haastrup Katrine Grau Jesper Eugen-Olsen Christian Thorball Lars Vedel Kessing Henrik Ullum
author_sort	Eva Haastrup
title	Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
title_short	Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
title_full	Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
title_fullStr	Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
title_full_unstemmed	Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
title_sort	soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/18601855b7964800aa51a051d0b182a9
work_keys_str_mv	AT evahaastrup solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants AT katrinegrau solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants AT jespereugenolsen solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants AT christianthorball solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants AT larsvedelkessing solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants AT henrikullum solubleurokinaseplasminogenactivatorreceptorasamarkerforuseofantidepressants
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Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants.

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