Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis

Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis

Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablat...

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Autores principales: Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, Young-Woo Jo, Ji-Hoon Kim, Sang-Hyeon Hann, Jieon Park, Inkuk Park, Hyerim Park, Kyusang Yoo, Joonwoo Rhee, Jung-Wee Park, Yong Chan Ha, Young-Yun Kong
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/186250f8decc4f9ea8ae3d425ceeb8b9
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spelling oai:doaj.org-article:186250f8decc4f9ea8ae3d425ceeb8b92021-12-02T13:32:57ZMaintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis10.1038/s41467-021-21621-62041-1723https://doaj.org/article/186250f8decc4f9ea8ae3d425ceeb8b92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21621-6https://doaj.org/toc/2041-1723Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.Ji-Yun SeoJong-Seol KangYe Lynne KimYoung-Woo JoJi-Hoon KimSang-Hyeon HannJieon ParkInkuk ParkHyerim ParkKyusang YooJoonwoo RheeJung-Wee ParkYong Chan HaYoung-Yun KongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ji-Yun Seo
Jong-Seol Kang
Ye Lynne Kim
Young-Woo Jo
Ji-Hoon Kim
Sang-Hyeon Hann
Jieon Park
Inkuk Park
Hyerim Park
Kyusang Yoo
Joonwoo Rhee
Jung-Wee Park
Yong Chan Ha
Young-Yun Kong
Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
description Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.
format article
author Ji-Yun Seo
Jong-Seol Kang
Ye Lynne Kim
Young-Woo Jo
Ji-Hoon Kim
Sang-Hyeon Hann
Jieon Park
Inkuk Park
Hyerim Park
Kyusang Yoo
Joonwoo Rhee
Jung-Wee Park
Yong Chan Ha
Young-Yun Kong
author_facet Ji-Yun Seo
Jong-Seol Kang
Ye Lynne Kim
Young-Woo Jo
Ji-Hoon Kim
Sang-Hyeon Hann
Jieon Park
Inkuk Park
Hyerim Park
Kyusang Yoo
Joonwoo Rhee
Jung-Wee Park
Yong Chan Ha
Young-Yun Kong
author_sort Ji-Yun Seo
title Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
title_short Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
title_full Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
title_fullStr Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
title_full_unstemmed Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
title_sort maintenance of type 2 glycolytic myofibers with age by mib1-actn3 axis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/186250f8decc4f9ea8ae3d425ceeb8b9
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