Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

R Dinarvand1,2, N Sepehri1, S Manoochehri1, H Rouhani1, F Atyabi1,21Department of Pharmaceutics, Faculty of Pharmacy, 2Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, IranAbstract: The effectiveness of anticancer agents may be hindered by low solubility in water, poor...

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Autores principales:	Rouhani H, Manoochehri S, Sepehri N, R, Atyabi F, Dinarv
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/186619282f5c4b89b205f8edba484838
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spelling	oai:doaj.org-article:186619282f5c4b89b205f8edba4848382021-12-02T07:36:59ZPolylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents1176-91141178-2013https://doaj.org/article/186619282f5c4b89b205f8edba4848382011-04-01T00:00:00Zhttp://www.dovepress.com/polylactide-co-glycolide-nanoparticles-for-controlled-delivery-of-anti-a7245https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013R Dinarvand1,2, N Sepehri1, S Manoochehri1, H Rouhani1, F Atyabi1,21Department of Pharmaceutics, Faculty of Pharmacy, 2Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, IranAbstract: The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.Keywords: nanotechnology, polymeric nanocarriers, targeting, anticancer agents, surface modificationRouhani HManoochehri SSepehri NRAtyabi FDinarvDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 877-895 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rouhani H Manoochehri S Sepehri N R Atyabi F Dinarv Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
description	R Dinarvand1,2, N Sepehri1, S Manoochehri1, H Rouhani1, F Atyabi1,21Department of Pharmaceutics, Faculty of Pharmacy, 2Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, IranAbstract: The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.Keywords: nanotechnology, polymeric nanocarriers, targeting, anticancer agents, surface modification
format	article
author	Rouhani H Manoochehri S Sepehri N R Atyabi F Dinarv
author_facet	Rouhani H Manoochehri S Sepehri N R Atyabi F Dinarv
author_sort	Rouhani H
title	Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
title_short	Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
title_full	Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
title_fullStr	Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
title_full_unstemmed	Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
title_sort	polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/186619282f5c4b89b205f8edba484838
work_keys_str_mv	AT rouhanih polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents AT manoochehris polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents AT sepehrin polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents AT r polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents AT atyabif polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents AT dinarv polylactidecoglycolidenanoparticlesforcontrolleddeliveryofanticanceragents
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Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

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