CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenqiang Cao, Jing Guo, Xiaofeng Wen, Li Miao, Feng Lin, Guanxin Xu, Ruoyu Ma, Shengxia Yin, Zhaoyuan Hui, Tingting Chen, Shixin Guo, Wei Chen, Yingying Huang, Yizhi Liu, Jianli Wang, Lai Wei, Lie Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/186e362a991647ddb613f7f820da2fe6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:186e362a991647ddb613f7f820da2fe6
record_format	dspace
spelling	oai:doaj.org-article:186e362a991647ddb613f7f820da2fe62021-12-02T14:39:34ZCXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation10.1038/ncomms116872041-1723https://doaj.org/article/186e362a991647ddb613f7f820da2fe62016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11687https://doaj.org/toc/2041-1723T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.Wenqiang CaoJing GuoXiaofeng WenLi MiaoFeng LinGuanxin XuRuoyu MaShengxia YinZhaoyuan HuiTingting ChenShixin GuoWei ChenYingying HuangYizhi LiuJianli WangLai WeiLie WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenqiang Cao Jing Guo Xiaofeng Wen Li Miao Feng Lin Guanxin Xu Ruoyu Ma Shengxia Yin Zhaoyuan Hui Tingting Chen Shixin Guo Wei Chen Yingying Huang Yizhi Liu Jianli Wang Lai Wei Lie Wang CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
description	T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.
format	article
author	Wenqiang Cao Jing Guo Xiaofeng Wen Li Miao Feng Lin Guanxin Xu Ruoyu Ma Shengxia Yin Zhaoyuan Hui Tingting Chen Shixin Guo Wei Chen Yingying Huang Yizhi Liu Jianli Wang Lai Wei Lie Wang
author_facet	Wenqiang Cao Jing Guo Xiaofeng Wen Li Miao Feng Lin Guanxin Xu Ruoyu Ma Shengxia Yin Zhaoyuan Hui Tingting Chen Shixin Guo Wei Chen Yingying Huang Yizhi Liu Jianli Wang Lai Wei Lie Wang
author_sort	Wenqiang Cao
title	CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
title_short	CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
title_full	CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
title_fullStr	CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
title_full_unstemmed	CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
title_sort	cxxc finger protein 1 is critical for t-cell intrathymic development through regulating h3k4 trimethylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/186e362a991647ddb613f7f820da2fe6
work_keys_str_mv	AT wenqiangcao cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT jingguo cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT xiaofengwen cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT limiao cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT fenglin cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT guanxinxu cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT ruoyuma cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT shengxiayin cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT zhaoyuanhui cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT tingtingchen cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT shixinguo cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT weichen cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT yingyinghuang cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT yizhiliu cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT jianliwang cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT laiwei cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation AT liewang cxxcfingerprotein1iscriticalfortcellintrathymicdevelopmentthroughregulatingh3k4trimethylation
_version_	1718390578776899584

CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

Ejemplares similares