Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protected from infection by CCR5-tropic (R5) virus strains. As an approach to inactivating CCR5, we introduc...

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Bibliographic Details
Main Authors: Craig B Wilen, Jianbin Wang, John C Tilton, Jeffrey C Miller, Kenneth A Kim, Edward J Rebar, Scott A Sherrill-Mix, Sean C Patro, Anthony J Secreto, Andrea P O Jordan, Gary Lee, Joshua Kahn, Pyone P Aye, Bruce A Bunnell, Andrew A Lackner, James A Hoxie, Gwenn A Danet-Desnoyers, Frederic D Bushman, James L Riley, Philip D Gregory, Carl H June, Michael C Holmes, Robert W Doms
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/186f7779921b432492a6f9af1a25f58c
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https://doaj.org/article/186f7779921b432492a6f9af1a25f58c

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