Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.
HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protected from infection by CCR5-tropic (R5) virus strains. As an approach to inactivating CCR5, we introduc...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2011
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/186f7779921b432492a6f9af1a25f58c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|