High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients

Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptoma...

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Autores principales:	Manuel Scimeca, Manuela Montanaro, Marina Cardellini, Rita Bonfiglio, Lucia Anemona, Nicoletta Urbano, Elena Bonanno, Rossella Menghini, Viviana Casagrande, Eugenio Martelli, Francesca Servadei, Erica Giacobbi, Arnaldo Ippoliti, Roberto Bei, Vittorio Manzari, Massimo Federici, Orazio Schillaci, Alessandro Mauriello
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atherosclerosis hs-CRP carotid plaque cardiovascular risk factors dyslipidemic patients Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/187382072b2d4cb093e5bfd537427c32
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spelling	oai:doaj.org-article:187382072b2d4cb093e5bfd537427c322021-11-25T17:21:46ZHigh Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients10.3390/diagnostics111121172075-4418https://doaj.org/article/187382072b2d4cb093e5bfd537427c322021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2117https://doaj.org/toc/2075-4418Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease.Manuel ScimecaManuela MontanaroMarina CardelliniRita BonfiglioLucia AnemonaNicoletta UrbanoElena BonannoRossella MenghiniViviana CasagrandeEugenio MartelliFrancesca ServadeiErica GiacobbiArnaldo IppolitiRoberto BeiVittorio ManzariMassimo FedericiOrazio SchillaciAlessandro MaurielloMDPI AGarticleatherosclerosishs-CRPcarotid plaquecardiovascular risk factorsdyslipidemic patientsMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2117, p 2117 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis hs-CRP carotid plaque cardiovascular risk factors dyslipidemic patients Medicine (General) R5-920
spellingShingle	atherosclerosis hs-CRP carotid plaque cardiovascular risk factors dyslipidemic patients Medicine (General) R5-920 Manuel Scimeca Manuela Montanaro Marina Cardellini Rita Bonfiglio Lucia Anemona Nicoletta Urbano Elena Bonanno Rossella Menghini Viviana Casagrande Eugenio Martelli Francesca Servadei Erica Giacobbi Arnaldo Ippoliti Roberto Bei Vittorio Manzari Massimo Federici Orazio Schillaci Alessandro Mauriello High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
description	Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease.
format	article
author	Manuel Scimeca Manuela Montanaro Marina Cardellini Rita Bonfiglio Lucia Anemona Nicoletta Urbano Elena Bonanno Rossella Menghini Viviana Casagrande Eugenio Martelli Francesca Servadei Erica Giacobbi Arnaldo Ippoliti Roberto Bei Vittorio Manzari Massimo Federici Orazio Schillaci Alessandro Mauriello
author_facet	Manuel Scimeca Manuela Montanaro Marina Cardellini Rita Bonfiglio Lucia Anemona Nicoletta Urbano Elena Bonanno Rossella Menghini Viviana Casagrande Eugenio Martelli Francesca Servadei Erica Giacobbi Arnaldo Ippoliti Roberto Bei Vittorio Manzari Massimo Federici Orazio Schillaci Alessandro Mauriello
author_sort	Manuel Scimeca
title	High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_short	High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_full	High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_fullStr	High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_full_unstemmed	High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_sort	high sensitivity c-reactive protein increases the risk of carotid plaque instability in male dyslipidemic patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/187382072b2d4cb093e5bfd537427c32
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High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients

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