Changes in salivary biomarkers of oxidative status in calves at weaning and grouping

Abstract Background Saliva is being increasingly used as a sample for measuring biomarkers in several species and shows a high potential of use to detect and monitor stress. The weaning and grouping in dairy calves are a particularly stressful time. Therefore, the objectives of this study were to ev...

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Autores principales: Camila Peres Rubio, Damián Escribano, Eva Mainau, José Joaquin Cerón, Elena Navarro, Xavier Manteca
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Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/18740607be3c4a5dba5c68ece9a2c5fe
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spelling oai:doaj.org-article:18740607be3c4a5dba5c68ece9a2c5fe2021-12-05T12:16:54ZChanges in salivary biomarkers of oxidative status in calves at weaning and grouping10.1186/s12917-021-03087-21746-6148https://doaj.org/article/18740607be3c4a5dba5c68ece9a2c5fe2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12917-021-03087-2https://doaj.org/toc/1746-6148Abstract Background Saliva is being increasingly used as a sample for measuring biomarkers in several species and shows a high potential of use to detect and monitor stress. The weaning and grouping in dairy calves are a particularly stressful time. Therefore, the objectives of this study were to evaluate a panel of antioxidant and oxidant biomarkers in the saliva of calves on the day of weaning (W0), 2 days after weaning or milk withdrawal (W + 2), and 4 days after grouping (G + 4). In addition, to verify if cortisol and oxytocin concentrations are related to the biomarkers measured. Results Salivary cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of saliva (FRAS), Trolox equivalent antioxidant capacity (TEAC), advanced oxidation protein products (AOPP), and ferrous oxidation-xylenol orange (FOX) were significantly higher (P < 0.02) 4 days after grouping than the day of weaning and 2 days after. The increases were 50 and 54% for CUPRAC, 93 and 116% for FRAS, 117 and 135% for TEAC, 22 and 49% for AOPP and 10 and 5% for FOX in comparison with weaning and 2 days after, respectively. In addition, oxytocin and cortisol showed significant negative and positive correlations (P < 0.05) respectively with the biomarkers of oxidative status. Conclusions Our results showed that calves after grouping show increases in antioxidants and oxidants concentrations, indicating that a balance between these molecules has been tried to maintain during this stressful situation. The dynamic changes of biomarkers of oxidative status should be explored and characterised in other stressful conditions.Camila Peres RubioDamián EscribanoEva MainauJosé Joaquin CerónElena NavarroXavier MantecaBMCarticleAntioxidantsCupricFerricOxidantStressVeterinary medicineSF600-1100ENBMC Veterinary Research, Vol 17, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Antioxidants
Cupric
Ferric
Oxidant
Stress
Veterinary medicine
SF600-1100
spellingShingle Antioxidants
Cupric
Ferric
Oxidant
Stress
Veterinary medicine
SF600-1100
Camila Peres Rubio
Damián Escribano
Eva Mainau
José Joaquin Cerón
Elena Navarro
Xavier Manteca
Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
description Abstract Background Saliva is being increasingly used as a sample for measuring biomarkers in several species and shows a high potential of use to detect and monitor stress. The weaning and grouping in dairy calves are a particularly stressful time. Therefore, the objectives of this study were to evaluate a panel of antioxidant and oxidant biomarkers in the saliva of calves on the day of weaning (W0), 2 days after weaning or milk withdrawal (W + 2), and 4 days after grouping (G + 4). In addition, to verify if cortisol and oxytocin concentrations are related to the biomarkers measured. Results Salivary cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of saliva (FRAS), Trolox equivalent antioxidant capacity (TEAC), advanced oxidation protein products (AOPP), and ferrous oxidation-xylenol orange (FOX) were significantly higher (P < 0.02) 4 days after grouping than the day of weaning and 2 days after. The increases were 50 and 54% for CUPRAC, 93 and 116% for FRAS, 117 and 135% for TEAC, 22 and 49% for AOPP and 10 and 5% for FOX in comparison with weaning and 2 days after, respectively. In addition, oxytocin and cortisol showed significant negative and positive correlations (P < 0.05) respectively with the biomarkers of oxidative status. Conclusions Our results showed that calves after grouping show increases in antioxidants and oxidants concentrations, indicating that a balance between these molecules has been tried to maintain during this stressful situation. The dynamic changes of biomarkers of oxidative status should be explored and characterised in other stressful conditions.
format article
author Camila Peres Rubio
Damián Escribano
Eva Mainau
José Joaquin Cerón
Elena Navarro
Xavier Manteca
author_facet Camila Peres Rubio
Damián Escribano
Eva Mainau
José Joaquin Cerón
Elena Navarro
Xavier Manteca
author_sort Camila Peres Rubio
title Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
title_short Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
title_full Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
title_fullStr Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
title_full_unstemmed Changes in salivary biomarkers of oxidative status in calves at weaning and grouping
title_sort changes in salivary biomarkers of oxidative status in calves at weaning and grouping
publisher BMC
publishDate 2021
url https://doaj.org/article/18740607be3c4a5dba5c68ece9a2c5fe
work_keys_str_mv AT camilaperesrubio changesinsalivarybiomarkersofoxidativestatusincalvesatweaningandgrouping
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AT evamainau changesinsalivarybiomarkersofoxidativestatusincalvesatweaningandgrouping
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AT elenanavarro changesinsalivarybiomarkersofoxidativestatusincalvesatweaningandgrouping
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