Daily electrical activity in the master circadian clock of a diurnal mammal

Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active...

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Autores principales:	Beatriz Bano-Otalora, Matthew J Moye, Timothy Brown, Robert J Lucas, Casey O Diekman, Mino DC Belle
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	diurnality circadian rhythms suprachiasmatic nucleus electrical activity mathematical modelling Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1875f52eaf6b46f2934c19d8c1df5fb4
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spelling	oai:doaj.org-article:1875f52eaf6b46f2934c19d8c1df5fb42021-11-30T12:30:41ZDaily electrical activity in the master circadian clock of a diurnal mammal10.7554/eLife.681792050-084Xe68179https://doaj.org/article/1875f52eaf6b46f2934c19d8c1df5fb42021-11-01T00:00:00Zhttps://elifesciences.org/articles/68179https://doaj.org/toc/2050-084XCircadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active animals remains unclear. Here, we recorded the spontaneous and evoked electrical activity of single SCN neurons in the diurnal rodent Rhabdomys pumilio, and developed cutting-edge data assimilation and mathematical modeling approaches to uncover the underlying ionic mechanisms. As in nocturnal rodents, R. pumilio SCN neurons were more excited during daytime hours. By contrast, the evoked activity of R. pumilio neurons included a prominent suppressive response that is not present in the SCN of nocturnal rodents. Our modeling revealed and subsequent experiments confirmed transient subthreshold A-type potassium channels as the primary determinant of this response, and suggest a key role for this ionic mechanism in optimizing SCN function to accommodate R. pumilio’s diurnal niche.Beatriz Bano-OtaloraMatthew J MoyeTimothy BrownRobert J LucasCasey O DiekmanMino DC BelleeLife Sciences Publications Ltdarticlediurnalitycircadian rhythmssuprachiasmatic nucleuselectrical activitymathematical modellingMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diurnality circadian rhythms suprachiasmatic nucleus electrical activity mathematical modelling Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	diurnality circadian rhythms suprachiasmatic nucleus electrical activity mathematical modelling Medicine R Science Q Biology (General) QH301-705.5 Beatriz Bano-Otalora Matthew J Moye Timothy Brown Robert J Lucas Casey O Diekman Mino DC Belle Daily electrical activity in the master circadian clock of a diurnal mammal
description	Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active animals remains unclear. Here, we recorded the spontaneous and evoked electrical activity of single SCN neurons in the diurnal rodent Rhabdomys pumilio, and developed cutting-edge data assimilation and mathematical modeling approaches to uncover the underlying ionic mechanisms. As in nocturnal rodents, R. pumilio SCN neurons were more excited during daytime hours. By contrast, the evoked activity of R. pumilio neurons included a prominent suppressive response that is not present in the SCN of nocturnal rodents. Our modeling revealed and subsequent experiments confirmed transient subthreshold A-type potassium channels as the primary determinant of this response, and suggest a key role for this ionic mechanism in optimizing SCN function to accommodate R. pumilio’s diurnal niche.
format	article
author	Beatriz Bano-Otalora Matthew J Moye Timothy Brown Robert J Lucas Casey O Diekman Mino DC Belle
author_facet	Beatriz Bano-Otalora Matthew J Moye Timothy Brown Robert J Lucas Casey O Diekman Mino DC Belle
author_sort	Beatriz Bano-Otalora
title	Daily electrical activity in the master circadian clock of a diurnal mammal
title_short	Daily electrical activity in the master circadian clock of a diurnal mammal
title_full	Daily electrical activity in the master circadian clock of a diurnal mammal
title_fullStr	Daily electrical activity in the master circadian clock of a diurnal mammal
title_full_unstemmed	Daily electrical activity in the master circadian clock of a diurnal mammal
title_sort	daily electrical activity in the master circadian clock of a diurnal mammal
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/1875f52eaf6b46f2934c19d8c1df5fb4
work_keys_str_mv	AT beatrizbanootalora dailyelectricalactivityinthemastercircadianclockofadiurnalmammal AT matthewjmoye dailyelectricalactivityinthemastercircadianclockofadiurnalmammal AT timothybrown dailyelectricalactivityinthemastercircadianclockofadiurnalmammal AT robertjlucas dailyelectricalactivityinthemastercircadianclockofadiurnalmammal AT caseyodiekman dailyelectricalactivityinthemastercircadianclockofadiurnalmammal AT minodcbelle dailyelectricalactivityinthemastercircadianclockofadiurnalmammal
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Daily electrical activity in the master circadian clock of a diurnal mammal

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