REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, pro...

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Autores principales:	Huairong Zhang, Andrea Liliam Gomez Corredor, Julia Messina-Pacheco, Qing Li, George Zogopoulos, Nancy Kaddour, Yifan Wang, Bing-yin Shi, Alex Gregorieff, Jun-li Liu, Zu-hua Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/187a4a144b6748659950952e1f8ad2db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:187a4a144b6748659950952e1f8ad2db2021-12-02T17:47:03ZREG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway10.1038/s42003-021-02193-z2399-3642https://doaj.org/article/187a4a144b6748659950952e1f8ad2db2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02193-zhttps://doaj.org/toc/2399-3642Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, providing new insights into PDAC development.Huairong ZhangAndrea Liliam Gomez CorredorJulia Messina-PachecoQing LiGeorge ZogopoulosNancy KaddourYifan WangBing-yin ShiAlex GregorieffJun-li LiuZu-hua GaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
description	Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, providing new insights into PDAC development.
format	article
author	Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao
author_facet	Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao
author_sort	Huairong Zhang
title	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_short	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_full	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_fullStr	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_full_unstemmed	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_sort	reg3a/reg3b promotes acinar to ductal metaplasia through binding to extl3 and activating the ras-raf-mek-erk signaling pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/187a4a144b6748659950952e1f8ad2db
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REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

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