B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allo...

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Autores principales:	Jason B. Wong, Susannah L. Hewitt, Lynn M. Heltemes-Harris, Malay Mandal, Kristen Johnson, Klaus Rajewsky, Sergei B. Koralov, Marcus R. Clark, Michael A. Farrar, Jane A. Skok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/187b8150da99438da49e30693e5b9441
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spelling	oai:doaj.org-article:187b8150da99438da49e30693e5b94412021-12-02T17:02:18ZB-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage10.1038/s41467-019-12824-z2041-1723https://doaj.org/article/187b8150da99438da49e30693e5b94412019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12824-zhttps://doaj.org/toc/2041-1723B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allowing the generation of autoreactive B1-a B cells.Jason B. WongSusannah L. HewittLynn M. Heltemes-HarrisMalay MandalKristen JohnsonKlaus RajewskySergei B. KoralovMarcus R. ClarkMichael A. FarrarJane A. SkokNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
description	B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allowing the generation of autoreactive B1-a B cells.
format	article
author	Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok
author_facet	Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok
author_sort	Jason B. Wong
title	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
title_short	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
title_full	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
title_fullStr	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
title_full_unstemmed	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
title_sort	b-1a cells acquire their unique characteristics by bypassing the pre-bcr selection stage
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/187b8150da99438da49e30693e5b9441
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B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

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