Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.

Saved in:

Bibliographic Details
Main Authors:	Fangfang Zhang, Dongshen Ma, Wanli Zhao, Danwei Wang, Tingsheng Liu, Yuhong Liu, Yue Yang, Yue Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu, Zhengyu Cao, Liang Jin
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/187f64262ed142f792b8537b08d22b51
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Similar Items