Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.

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Autores principales:	Fangfang Zhang, Dongshen Ma, Wanli Zhao, Danwei Wang, Tingsheng Liu, Yuhong Liu, Yue Yang, Yue Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu, Zhengyu Cao, Liang Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/187f64262ed142f792b8537b08d22b51
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spelling	oai:doaj.org-article:187f64262ed142f792b8537b08d22b512021-12-02T14:40:41ZObesity-induced overexpression of miR-802 impairs insulin transcription and secretion10.1038/s41467-020-15529-w2041-1723https://doaj.org/article/187f64262ed142f792b8537b08d22b512020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15529-whttps://doaj.org/toc/2041-1723Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.Fangfang ZhangDongshen MaWanli ZhaoDanwei WangTingsheng LiuYuhong LiuYue YangYue LiuJinming MuBingbing LiYanfeng ZhangYi PanChangying GuoHong DuLing LiXianghui FuZhengyu CaoLiang JinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fangfang Zhang Dongshen Ma Wanli Zhao Danwei Wang Tingsheng Liu Yuhong Liu Yue Yang Yue Liu Jinming Mu Bingbing Li Yanfeng Zhang Yi Pan Changying Guo Hong Du Ling Li Xianghui Fu Zhengyu Cao Liang Jin Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
description	Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.
format	article
author	Fangfang Zhang Dongshen Ma Wanli Zhao Danwei Wang Tingsheng Liu Yuhong Liu Yue Yang Yue Liu Jinming Mu Bingbing Li Yanfeng Zhang Yi Pan Changying Guo Hong Du Ling Li Xianghui Fu Zhengyu Cao Liang Jin
author_facet	Fangfang Zhang Dongshen Ma Wanli Zhao Danwei Wang Tingsheng Liu Yuhong Liu Yue Yang Yue Liu Jinming Mu Bingbing Li Yanfeng Zhang Yi Pan Changying Guo Hong Du Ling Li Xianghui Fu Zhengyu Cao Liang Jin
author_sort	Fangfang Zhang
title	Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
title_short	Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
title_full	Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
title_fullStr	Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
title_full_unstemmed	Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
title_sort	obesity-induced overexpression of mir-802 impairs insulin transcription and secretion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/187f64262ed142f792b8537b08d22b51
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Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

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