Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.

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Autores principales: Fangfang Zhang, Dongshen Ma, Wanli Zhao, Danwei Wang, Tingsheng Liu, Yuhong Liu, Yue Yang, Yue Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu, Zhengyu Cao, Liang Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/187f64262ed142f792b8537b08d22b51
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https://doaj.org/article/187f64262ed142f792b8537b08d22b51

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