Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
Obesity predisposes to type 2 diabetes, but the mechanisms of obesity-associated β cell dysfunction are incompletely understood. Here the authors report that obesity increases the levels of miR-802, which impairs insulin transcription and secretion by targeting NeuroD1 and Fzd5.
Guardado en:
Autores principales: | Fangfang Zhang, Dongshen Ma, Wanli Zhao, Danwei Wang, Tingsheng Liu, Yuhong Liu, Yue Yang, Yue Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu, Zhengyu Cao, Liang Jin |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/187f64262ed142f792b8537b08d22b51 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Acta Nº802
por: Banco Central de Chile
Publicado: (2019) -
Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
por: Tao Yuan, et al.
Publicado: (2021) -
The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
por: Fangfang Zhang, et al.
Publicado: (2021) -
Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion.
por: Sarah Hudak, et al.
Publicado: (2021) -
Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
por: Sarah Hudak, et al.
Publicado: (2021)