Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape

Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit it...

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Autores principales:	Ahmed A. Quadeer, John P. Barton, Arup K. Chakraborty, Matthew R. McKay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/188a3383b3ff497ca1c0cc5ab11684bc
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spelling	oai:doaj.org-article:188a3383b3ff497ca1c0cc5ab11684bc2021-12-02T16:50:00ZDeconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape10.1038/s41467-019-14174-22041-1723https://doaj.org/article/188a3383b3ff497ca1c0cc5ab11684bc2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14174-2https://doaj.org/toc/2041-1723Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit its ability to avoid vaccine-induced immune responses.Ahmed A. QuadeerJohn P. BartonArup K. ChakrabortyMatthew R. McKayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmed A. Quadeer John P. Barton Arup K. Chakraborty Matthew R. McKay Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
description	Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit its ability to avoid vaccine-induced immune responses.
format	article
author	Ahmed A. Quadeer John P. Barton Arup K. Chakraborty Matthew R. McKay
author_facet	Ahmed A. Quadeer John P. Barton Arup K. Chakraborty Matthew R. McKay
author_sort	Ahmed A. Quadeer
title	Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
title_short	Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
title_full	Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
title_fullStr	Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
title_full_unstemmed	Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
title_sort	deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/188a3383b3ff497ca1c0cc5ab11684bc
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Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape

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