Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape

Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit it...

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Autores principales: Ahmed A. Quadeer, John P. Barton, Arup K. Chakraborty, Matthew R. McKay
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/188a3383b3ff497ca1c0cc5ab11684bc
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