The distribution of antibiotic resistance genes in chicken gut microbiota commensals

Abstract Antibiotic resistance in bacterial pathogens or several indicator bacteria is commonly studied but the extent of antibiotic resistance in bacterial commensals colonising the intestinal tract is essentially unknown. In this study, we aimed to investigate the presence of horizontally acquired...

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Autores principales:	Helena Juricova, Jitka Matiasovicova, Tereza Kubasova, Darina Cejkova, Ivan Rychlik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/188b5ac220304367b9d2e21273626012
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spelling	oai:doaj.org-article:188b5ac220304367b9d2e212736260122021-12-02T13:30:34ZThe distribution of antibiotic resistance genes in chicken gut microbiota commensals10.1038/s41598-021-82640-32045-2322https://doaj.org/article/188b5ac220304367b9d2e212736260122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82640-3https://doaj.org/toc/2045-2322Abstract Antibiotic resistance in bacterial pathogens or several indicator bacteria is commonly studied but the extent of antibiotic resistance in bacterial commensals colonising the intestinal tract is essentially unknown. In this study, we aimed to investigate the presence of horizontally acquired antibiotic resistance genes among chicken gut microbiota members in 259 isolates with known whole genomic sequences. Altogether 124 isolates contained at least one gene coding for antibiotic resistance. Genes coding for the resistance to tetracyclines (detected in 101 isolates), macrolide-lincosamide-streptogramin B antibiotics (28 isolates) and aminoglycosides (25 isolates) were the most common. The most frequent tetracycline resistance genes were tet(W), tet(32), tet(O) and tet(Q). Lachnospiraceae and Ruminococcaceae frequently encoded tet(W). Lachnospiraceae commonly coded also for tet(32) and tet(O). The tet(44) gene was associated with Erysipelotrichaceae and tet(Q) was detected in the genomes of Bacteroidaceae and Porphyromonadaceae. Without any bias we have shown that antibiotic resistance is quite common in gut commensals. However, a comparison of codon usage showed that the above-mentioned families represent the most common current reservoirs but probably not the original host of the detected resistances.Helena JuricovaJitka MatiasovicovaTereza KubasovaDarina CejkovaIvan RychlikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Helena Juricova Jitka Matiasovicova Tereza Kubasova Darina Cejkova Ivan Rychlik The distribution of antibiotic resistance genes in chicken gut microbiota commensals
description	Abstract Antibiotic resistance in bacterial pathogens or several indicator bacteria is commonly studied but the extent of antibiotic resistance in bacterial commensals colonising the intestinal tract is essentially unknown. In this study, we aimed to investigate the presence of horizontally acquired antibiotic resistance genes among chicken gut microbiota members in 259 isolates with known whole genomic sequences. Altogether 124 isolates contained at least one gene coding for antibiotic resistance. Genes coding for the resistance to tetracyclines (detected in 101 isolates), macrolide-lincosamide-streptogramin B antibiotics (28 isolates) and aminoglycosides (25 isolates) were the most common. The most frequent tetracycline resistance genes were tet(W), tet(32), tet(O) and tet(Q). Lachnospiraceae and Ruminococcaceae frequently encoded tet(W). Lachnospiraceae commonly coded also for tet(32) and tet(O). The tet(44) gene was associated with Erysipelotrichaceae and tet(Q) was detected in the genomes of Bacteroidaceae and Porphyromonadaceae. Without any bias we have shown that antibiotic resistance is quite common in gut commensals. However, a comparison of codon usage showed that the above-mentioned families represent the most common current reservoirs but probably not the original host of the detected resistances.
format	article
author	Helena Juricova Jitka Matiasovicova Tereza Kubasova Darina Cejkova Ivan Rychlik
author_facet	Helena Juricova Jitka Matiasovicova Tereza Kubasova Darina Cejkova Ivan Rychlik
author_sort	Helena Juricova
title	The distribution of antibiotic resistance genes in chicken gut microbiota commensals
title_short	The distribution of antibiotic resistance genes in chicken gut microbiota commensals
title_full	The distribution of antibiotic resistance genes in chicken gut microbiota commensals
title_fullStr	The distribution of antibiotic resistance genes in chicken gut microbiota commensals
title_full_unstemmed	The distribution of antibiotic resistance genes in chicken gut microbiota commensals
title_sort	distribution of antibiotic resistance genes in chicken gut microbiota commensals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/188b5ac220304367b9d2e21273626012
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The distribution of antibiotic resistance genes in chicken gut microbiota commensals

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