A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies
Abstract Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-generated mutational signatures depe...
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Autores principales: | Philip R. Davidson, Amy L. Sherborne, Barry Taylor, Alice O. Nakamura, Jean L. Nakamura |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/18916e3fad1b4077bd253d4b9366ceb3 |
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