A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

Abstract Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC). Methods The lipid metabolism statuses of 500 CRC pat...

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Autores principales:	Chao Yang, Shuoyang Huang, Fengyu Cao, Yongbin Zheng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Colorectal cancer Lipid metabolism-related genes Prognostic value Tumor immune microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/18942a53d8024de0a3e09ee9110e38d9
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spelling	oai:doaj.org-article:18942a53d8024de0a3e09ee9110e38d92021-11-08T11:01:49ZA lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma10.1186/s12885-021-08902-51471-2407https://doaj.org/article/18942a53d8024de0a3e09ee9110e38d92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08902-5https://doaj.org/toc/1471-2407Abstract Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC). Methods The lipid metabolism statuses of 500 CRC patients from the Cancer Genome Atlas (TCGA) and 523 from the Gene Expression Omnibus (GEO GSE39582) database were analyzed. The risk signature was constructed by univariate Cox regression and least absolute shrinkage and selection operator (LASSO) Cox regression. Results A novel four-LMRG signature (PROCA1, CCKBR, CPT2, and FDFT1) was constructed to predict clinical outcomes in CRC patients. The risk signature was shown to be an independent prognostic factor for CRC and was associated with tumour malignancy. Principal components analysis demonstrated that the risk signature could distinguish between low- and high-risk patients. There were significantly differences in abundances of tumor-infiltrating immune cells and mutational landscape between the two risk groups. Patients in the low-risk group were more likely to have higher tumor mutational burden, stem cell characteristics, and higher PD-L1 expression levels. Furthermore, a genomic-clinicopathologic nomogram was established and shown to be a more effective risk stratification tool than any clinical parameter alone. Conclusions This study demonstrated the prognostic value of LMRG and showed that they may be partially involved in the suppressive immune microenvironment formation.Chao YangShuoyang HuangFengyu CaoYongbin ZhengBMCarticleColorectal cancerLipid metabolism-related genesPrognostic valueTumor immune microenvironmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Colorectal cancer Lipid metabolism-related genes Prognostic value Tumor immune microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Colorectal cancer Lipid metabolism-related genes Prognostic value Tumor immune microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chao Yang Shuoyang Huang Fengyu Cao Yongbin Zheng A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
description	Abstract Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC). Methods The lipid metabolism statuses of 500 CRC patients from the Cancer Genome Atlas (TCGA) and 523 from the Gene Expression Omnibus (GEO GSE39582) database were analyzed. The risk signature was constructed by univariate Cox regression and least absolute shrinkage and selection operator (LASSO) Cox regression. Results A novel four-LMRG signature (PROCA1, CCKBR, CPT2, and FDFT1) was constructed to predict clinical outcomes in CRC patients. The risk signature was shown to be an independent prognostic factor for CRC and was associated with tumour malignancy. Principal components analysis demonstrated that the risk signature could distinguish between low- and high-risk patients. There were significantly differences in abundances of tumor-infiltrating immune cells and mutational landscape between the two risk groups. Patients in the low-risk group were more likely to have higher tumor mutational burden, stem cell characteristics, and higher PD-L1 expression levels. Furthermore, a genomic-clinicopathologic nomogram was established and shown to be a more effective risk stratification tool than any clinical parameter alone. Conclusions This study demonstrated the prognostic value of LMRG and showed that they may be partially involved in the suppressive immune microenvironment formation.
format	article
author	Chao Yang Shuoyang Huang Fengyu Cao Yongbin Zheng
author_facet	Chao Yang Shuoyang Huang Fengyu Cao Yongbin Zheng
author_sort	Chao Yang
title	A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
title_short	A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
title_full	A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
title_fullStr	A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
title_full_unstemmed	A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
title_sort	lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/18942a53d8024de0a3e09ee9110e38d9
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_version_	1718442402664939520

A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

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