Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

Abstract Polypoidal choroidal vasculopathy (PCV) is a vision-threatening disease common in Asian populations. However, the optimal treatment for PCV remains under debate. We searched the databases with optimal searching strategy. The study included randomized clinical trials and prospective studies...

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Autores principales:	Sheng-Chu Chi, Yi-No Kang, Yi-Ming Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18959247d9664eadbbeb7d2f5da21d59
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spelling	oai:doaj.org-article:18959247d9664eadbbeb7d2f5da21d592021-12-02T10:44:09ZSystematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy10.1038/s41598-021-82316-y2045-2322https://doaj.org/article/18959247d9664eadbbeb7d2f5da21d592021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82316-yhttps://doaj.org/toc/2045-2322Abstract Polypoidal choroidal vasculopathy (PCV) is a vision-threatening disease common in Asian populations. However, the optimal treatment for PCV remains under debate. We searched the databases with optimal searching strategy. The study included randomized clinical trials and prospective studies that recruited patients with active PCV who had received interventions, including PDT, anti-VEGF, or a combination of PDT and anti-VEGF. The Grading of Recommendations Assessment, Development, and Evaluation methodology was used for rating the quality of evidence. Our study included 11 studies involving 1277 patients. The network meta-analysis of RCTs revealed the anti-VEGF group, early combination group, and late combination group had significant BCVA changes compared with the PDT group. Early combination therapy led to a significant decrease in CRT compared with PDT, anti-VEGF, and late combination therapy. Additionally, the early combination group had a significantly higher complete polyp regression rate than the anti-VEGF group. No significant differences were detected in the analysis of the number of anti-VEGF injections and safety profile. This network meta-analysis revealed that early combination therapy exhibited better efficacy related to anatomical outcomes than other therapies. Nonetheless, no significant differences related to BCVA change could be detected between anti-VEGF and late combination therapy.Sheng-Chu ChiYi-No KangYi-Ming HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sheng-Chu Chi Yi-No Kang Yi-Ming Huang Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
description	Abstract Polypoidal choroidal vasculopathy (PCV) is a vision-threatening disease common in Asian populations. However, the optimal treatment for PCV remains under debate. We searched the databases with optimal searching strategy. The study included randomized clinical trials and prospective studies that recruited patients with active PCV who had received interventions, including PDT, anti-VEGF, or a combination of PDT and anti-VEGF. The Grading of Recommendations Assessment, Development, and Evaluation methodology was used for rating the quality of evidence. Our study included 11 studies involving 1277 patients. The network meta-analysis of RCTs revealed the anti-VEGF group, early combination group, and late combination group had significant BCVA changes compared with the PDT group. Early combination therapy led to a significant decrease in CRT compared with PDT, anti-VEGF, and late combination therapy. Additionally, the early combination group had a significantly higher complete polyp regression rate than the anti-VEGF group. No significant differences were detected in the analysis of the number of anti-VEGF injections and safety profile. This network meta-analysis revealed that early combination therapy exhibited better efficacy related to anatomical outcomes than other therapies. Nonetheless, no significant differences related to BCVA change could be detected between anti-VEGF and late combination therapy.
format	article
author	Sheng-Chu Chi Yi-No Kang Yi-Ming Huang
author_facet	Sheng-Chu Chi Yi-No Kang Yi-Ming Huang
author_sort	Sheng-Chu Chi
title	Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
title_short	Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
title_full	Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
title_fullStr	Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
title_full_unstemmed	Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
title_sort	systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/18959247d9664eadbbeb7d2f5da21d59
work_keys_str_mv	AT shengchuchi systematicreviewwithnetworkmetaanalysisofantivascularendothelialgrowthfactoruseinmanagingpolypoidalchoroidalvasculopathy AT yinokang systematicreviewwithnetworkmetaanalysisofantivascularendothelialgrowthfactoruseinmanagingpolypoidalchoroidalvasculopathy AT yiminghuang systematicreviewwithnetworkmetaanalysisofantivascularendothelialgrowthfactoruseinmanagingpolypoidalchoroidalvasculopathy
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Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

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