Potentiating antibiotic efficacy via perturbation of non-essential gene expression

Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in...

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Autores principales:	Peter B. Otoupal, Kristen A. Eller, Keesha E. Erickson, Jocelyn Campos, Thomas R. Aunins, Anushree Chatterjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1897d57a87004ebaa77d9c5fc86ebd05
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spelling	oai:doaj.org-article:1897d57a87004ebaa77d9c5fc86ebd052021-11-07T12:20:07ZPotentiating antibiotic efficacy via perturbation of non-essential gene expression10.1038/s42003-021-02783-x2399-3642https://doaj.org/article/1897d57a87004ebaa77d9c5fc86ebd052021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02783-xhttps://doaj.org/toc/2399-3642Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in multi-drug resistant E. coli and Klebisiella pneumoniae clinical isolates.Peter B. OtoupalKristen A. EllerKeesha E. EricksonJocelyn CamposThomas R. AuninsAnushree ChatterjeeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Peter B. Otoupal Kristen A. Eller Keesha E. Erickson Jocelyn Campos Thomas R. Aunins Anushree Chatterjee Potentiating antibiotic efficacy via perturbation of non-essential gene expression
description	Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in multi-drug resistant E. coli and Klebisiella pneumoniae clinical isolates.
format	article
author	Peter B. Otoupal Kristen A. Eller Keesha E. Erickson Jocelyn Campos Thomas R. Aunins Anushree Chatterjee
author_facet	Peter B. Otoupal Kristen A. Eller Keesha E. Erickson Jocelyn Campos Thomas R. Aunins Anushree Chatterjee
author_sort	Peter B. Otoupal
title	Potentiating antibiotic efficacy via perturbation of non-essential gene expression
title_short	Potentiating antibiotic efficacy via perturbation of non-essential gene expression
title_full	Potentiating antibiotic efficacy via perturbation of non-essential gene expression
title_fullStr	Potentiating antibiotic efficacy via perturbation of non-essential gene expression
title_full_unstemmed	Potentiating antibiotic efficacy via perturbation of non-essential gene expression
title_sort	potentiating antibiotic efficacy via perturbation of non-essential gene expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1897d57a87004ebaa77d9c5fc86ebd05
work_keys_str_mv	AT peterbotoupal potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression AT kristenaeller potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression AT keeshaeerickson potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression AT jocelyncampos potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression AT thomasraunins potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression AT anushreechatterjee potentiatingantibioticefficacyviaperturbationofnonessentialgeneexpression
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Potentiating antibiotic efficacy via perturbation of non-essential gene expression

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