Phytofabrication of bioinduced silver nanoparticles for biomedical applications

Nabeel Ahmad,1 Sharad Bhatnagar,1 Syed Salman Ali,2 Rajiv Dutta3 1School of Biotechnology, 2School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India; 3Institute of Bio-Science and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh,...

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Autores principales:	Ahmad N, Bhatnagar S, Ali SS, Dutta R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/18991eadaa56499392e5f97ab20c8137
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spelling	oai:doaj.org-article:18991eadaa56499392e5f97ab20c81372021-12-02T06:33:30ZPhytofabrication of bioinduced silver nanoparticles for biomedical applications1178-2013https://doaj.org/article/18991eadaa56499392e5f97ab20c81372015-11-01T00:00:00Zhttps://www.dovepress.com/phytofabrication-of-bioinduced-silver-nanoparticles-for-biomedical-app-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nabeel Ahmad,1 Sharad Bhatnagar,1 Syed Salman Ali,2 Rajiv Dutta3 1School of Biotechnology, 2School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India; 3Institute of Bio-Science and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India Abstract: Synthesis of nanomaterials holds infinite possibilities as nanotechnology is revolutionizing the field of medicine by its myriad applications. Green synthesis of nanoparticles has become the need of the hour because of its eco-friendly, nontoxic, and economic nature. In this study, leaf extract of Rosa damascena was used as a bioreductant to reduce silver nitrate, leading to synthesis of silver nanoparticles (AgNPs) in a single step, without the use of any additional reducing or capping agents. The synthesized nanoparticles were characterized by the use of UV-visible spectroscopy, fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and field emission scanning electron microscopy. Time-dependent synthesis of AgNPs was studied spectrophotometrically. Synthesized AgNPs were found to possess flower-like spherical structure where individual nanoparticles were of 16 nm in diameter, whereas the agglomerated AgNPs were in the range of 60–80 nm. These biologically synthesized AgNPs exhibited significant antibacterial activity against Gram-negative bacterial species but not against Gram-positive ones (Escherichia coli and Bacillus cereus). Anti-inflammatory and analgesic activities were studied on a Wistar rat model to gauge the impact of AgNPs for a probable role in these applications. AgNPs tested positive for both these activities, although the potency was less as compared to the standard drugs. Keywords: silver nanoparticles, green synthesis, anti-inflammatory, analgesic, animal model study, antibacterialAhmad NBhatnagar SAli SSDutta RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 7019-7030 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ahmad N Bhatnagar S Ali SS Dutta R Phytofabrication of bioinduced silver nanoparticles for biomedical applications
description	Nabeel Ahmad,1 Sharad Bhatnagar,1 Syed Salman Ali,2 Rajiv Dutta3 1School of Biotechnology, 2School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India; 3Institute of Bio-Science and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India Abstract: Synthesis of nanomaterials holds infinite possibilities as nanotechnology is revolutionizing the field of medicine by its myriad applications. Green synthesis of nanoparticles has become the need of the hour because of its eco-friendly, nontoxic, and economic nature. In this study, leaf extract of Rosa damascena was used as a bioreductant to reduce silver nitrate, leading to synthesis of silver nanoparticles (AgNPs) in a single step, without the use of any additional reducing or capping agents. The synthesized nanoparticles were characterized by the use of UV-visible spectroscopy, fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and field emission scanning electron microscopy. Time-dependent synthesis of AgNPs was studied spectrophotometrically. Synthesized AgNPs were found to possess flower-like spherical structure where individual nanoparticles were of 16 nm in diameter, whereas the agglomerated AgNPs were in the range of 60–80 nm. These biologically synthesized AgNPs exhibited significant antibacterial activity against Gram-negative bacterial species but not against Gram-positive ones (Escherichia coli and Bacillus cereus). Anti-inflammatory and analgesic activities were studied on a Wistar rat model to gauge the impact of AgNPs for a probable role in these applications. AgNPs tested positive for both these activities, although the potency was less as compared to the standard drugs. Keywords: silver nanoparticles, green synthesis, anti-inflammatory, analgesic, animal model study, antibacterial
format	article
author	Ahmad N Bhatnagar S Ali SS Dutta R
author_facet	Ahmad N Bhatnagar S Ali SS Dutta R
author_sort	Ahmad N
title	Phytofabrication of bioinduced silver nanoparticles for biomedical applications
title_short	Phytofabrication of bioinduced silver nanoparticles for biomedical applications
title_full	Phytofabrication of bioinduced silver nanoparticles for biomedical applications
title_fullStr	Phytofabrication of bioinduced silver nanoparticles for biomedical applications
title_full_unstemmed	Phytofabrication of bioinduced silver nanoparticles for biomedical applications
title_sort	phytofabrication of bioinduced silver nanoparticles for biomedical applications
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/18991eadaa56499392e5f97ab20c8137
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Phytofabrication of bioinduced silver nanoparticles for biomedical applications

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