Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.

<h4>Background</h4>The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains af...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	José E Meca-Lallana, Jorge Maurino, Francisco Pérez-Miralles, Lucía Forero, María Sepúlveda, Carmen Calles, María L Martínez-Ginés, Inés González-Suárez, Sabas Boyero, Lucía Romero-Pinel, Ángel P Sempere, Virginia Meca-Lallana, Luis Querol, Lucienne Costa-Frossard, Daniel Prefasi, Rocío Gómez-Ballesteros, Javier Ballesteros
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/189bfa11ecd7489bb2290d28a62384b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:189bfa11ecd7489bb2290d28a62384b2
record_format	dspace
spelling	oai:doaj.org-article:189bfa11ecd7489bb2290d28a62384b22021-12-02T20:08:54ZQuantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.1932-620310.1371/journal.pone.0255317https://doaj.org/article/189bfa11ecd7489bb2290d28a62384b22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255317https://doaj.org/toc/1932-6203<h4>Background</h4>The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD.<h4>Methods</h4>A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A non-parametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4.0.3) using the mokken library.<h4>Results</h4>A total of 70 patients were studied (mean age: 47.5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3.0 [interquartile range 1.5, 4.5]). Symptom severity was low (median SyMS score: 19.0 [interquartile range 10.0, 32.0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0.90 [95% confidence interval 0.86, 0.93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0.30. The overall SyMS scalability was 0.45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0.586), and physical and psychological quality of life (rho: 0.856 and 0.696, respectively).<h4>Conclusions</h4>The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.José E Meca-LallanaJorge MaurinoFrancisco Pérez-MirallesLucía ForeroMaría SepúlvedaCarmen CallesMaría L Martínez-GinésInés González-SuárezSabas BoyeroLucía Romero-PinelÁngel P SempereVirginia Meca-LallanaLuis QuerolLucienne Costa-FrossardDaniel PrefasiRocío Gómez-BallesterosJavier BallesterosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255317 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José E Meca-Lallana Jorge Maurino Francisco Pérez-Miralles Lucía Forero María Sepúlveda Carmen Calles María L Martínez-Ginés Inés González-Suárez Sabas Boyero Lucía Romero-Pinel Ángel P Sempere Virginia Meca-Lallana Luis Querol Lucienne Costa-Frossard Daniel Prefasi Rocío Gómez-Ballesteros Javier Ballesteros Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
description	<h4>Background</h4>The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD.<h4>Methods</h4>A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A non-parametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4.0.3) using the mokken library.<h4>Results</h4>A total of 70 patients were studied (mean age: 47.5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3.0 [interquartile range 1.5, 4.5]). Symptom severity was low (median SyMS score: 19.0 [interquartile range 10.0, 32.0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0.90 [95% confidence interval 0.86, 0.93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0.30. The overall SyMS scalability was 0.45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0.586), and physical and psychological quality of life (rho: 0.856 and 0.696, respectively).<h4>Conclusions</h4>The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.
format	article
author	José E Meca-Lallana Jorge Maurino Francisco Pérez-Miralles Lucía Forero María Sepúlveda Carmen Calles María L Martínez-Ginés Inés González-Suárez Sabas Boyero Lucía Romero-Pinel Ángel P Sempere Virginia Meca-Lallana Luis Querol Lucienne Costa-Frossard Daniel Prefasi Rocío Gómez-Ballesteros Javier Ballesteros
author_facet	José E Meca-Lallana Jorge Maurino Francisco Pérez-Miralles Lucía Forero María Sepúlveda Carmen Calles María L Martínez-Ginés Inés González-Suárez Sabas Boyero Lucía Romero-Pinel Ángel P Sempere Virginia Meca-Lallana Luis Querol Lucienne Costa-Frossard Daniel Prefasi Rocío Gómez-Ballesteros Javier Ballesteros
author_sort	José E Meca-Lallana
title	Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
title_short	Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
title_full	Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
title_fullStr	Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
title_full_unstemmed	Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
title_sort	quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: psychometric properties of the symptomscreen questionnaire.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/189bfa11ecd7489bb2290d28a62384b2
work_keys_str_mv	AT joseemecalallana quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT jorgemaurino quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT franciscoperezmiralles quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT luciaforero quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT mariasepulveda quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT carmencalles quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT marialmartinezgines quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT inesgonzalezsuarez quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT sabasboyero quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT luciaromeropinel quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT angelpsempere quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT virginiamecalallana quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT luisquerol quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT luciennecostafrossard quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT danielprefasi quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT rociogomezballesteros quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire AT javierballesteros quantifyingthepatientsperspectiveinneuromyelitisopticaspectrumdisorderpsychometricpropertiesofthesymptomscreenquestionnaire
_version_	1718375107581181952

Quantifying the patient´s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.

Ejemplares similares