Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India

Abstract Background Etiology of male infertility is intriguing and Y chromosome microdeletion within azoospermia factor (AZF) sub‐regions is considered major cause. We conducted a screening for Y chromosome microdeletion in an infertile male cohort from West Bengal, India to characterize Y chromosom...

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Autores principales:	Saurav Dutta, Pranab Paladhi, Samudra Pal, Gunja Bose, Papiya Ghosh, Ratna Chattopadhyay, Baidyanath Chakravarty, Sujay Ghosh
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	azoospermia azoospermia factor male infertility severe oligozoospermia Y‐chromosome microdeletion Genetics QH426-470
Acceso en línea:	https://doaj.org/article/189de64821084ac18bbbe10d3cde83fb
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spelling	oai:doaj.org-article:189de64821084ac18bbbe10d3cde83fb2021-11-10T16:39:23ZPrevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India2324-926910.1002/mgg3.1769https://doaj.org/article/189de64821084ac18bbbe10d3cde83fb2021-10-01T00:00:00Zhttps://doi.org/10.1002/mgg3.1769https://doaj.org/toc/2324-9269Abstract Background Etiology of male infertility is intriguing and Y chromosome microdeletion within azoospermia factor (AZF) sub‐regions is considered major cause. We conducted a screening for Y chromosome microdeletion in an infertile male cohort from West Bengal, India to characterize Y chromosome microdeletion among infertile men. Methods We recruited case subjects that were categorized on the basis of sperm count as azoospermia (N = 63), severe oligozoospermia (N = 38), and oligozoospermia (N = 17) and compared them with age, demography, and ethnicity matched healthy proven fertile control males (N = 84). Sequence Tagged Site makers and polymerase chain reaction based profiling of Y chromosome was done for AZF region and SRY for cases and controls. Results We scored 16.1% of cases (19 out of 118) that bear one or more microdeletions in the studied loci and none among the controls. The aberrations were more frequent among azoospermic males (17 of 19) than in severe oligozoospermic subjects (2 of 19). Conclusion Our study provides the results of screening of the largest Bengali infertile men sample genotyped with the maximum number of STS markers spanning the entire length of Y chromosome long arm. Y chromosome microdeletion is a significant genetic etiology of infertility among Bengali men.Saurav DuttaPranab PaladhiSamudra PalGunja BosePapiya GhoshRatna ChattopadhyayBaidyanath ChakravartySujay GhoshWileyarticleazoospermiaazoospermia factormale infertilitysevere oligozoospermiaY‐chromosome microdeletionGeneticsQH426-470ENMolecular Genetics & Genomic Medicine, Vol 9, Iss 10, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	azoospermia azoospermia factor male infertility severe oligozoospermia Y‐chromosome microdeletion Genetics QH426-470
spellingShingle	azoospermia azoospermia factor male infertility severe oligozoospermia Y‐chromosome microdeletion Genetics QH426-470 Saurav Dutta Pranab Paladhi Samudra Pal Gunja Bose Papiya Ghosh Ratna Chattopadhyay Baidyanath Chakravarty Sujay Ghosh Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
description	Abstract Background Etiology of male infertility is intriguing and Y chromosome microdeletion within azoospermia factor (AZF) sub‐regions is considered major cause. We conducted a screening for Y chromosome microdeletion in an infertile male cohort from West Bengal, India to characterize Y chromosome microdeletion among infertile men. Methods We recruited case subjects that were categorized on the basis of sperm count as azoospermia (N = 63), severe oligozoospermia (N = 38), and oligozoospermia (N = 17) and compared them with age, demography, and ethnicity matched healthy proven fertile control males (N = 84). Sequence Tagged Site makers and polymerase chain reaction based profiling of Y chromosome was done for AZF region and SRY for cases and controls. Results We scored 16.1% of cases (19 out of 118) that bear one or more microdeletions in the studied loci and none among the controls. The aberrations were more frequent among azoospermic males (17 of 19) than in severe oligozoospermic subjects (2 of 19). Conclusion Our study provides the results of screening of the largest Bengali infertile men sample genotyped with the maximum number of STS markers spanning the entire length of Y chromosome long arm. Y chromosome microdeletion is a significant genetic etiology of infertility among Bengali men.
format	article
author	Saurav Dutta Pranab Paladhi Samudra Pal Gunja Bose Papiya Ghosh Ratna Chattopadhyay Baidyanath Chakravarty Sujay Ghosh
author_facet	Saurav Dutta Pranab Paladhi Samudra Pal Gunja Bose Papiya Ghosh Ratna Chattopadhyay Baidyanath Chakravarty Sujay Ghosh
author_sort	Saurav Dutta
title	Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
title_short	Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
title_full	Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
title_fullStr	Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
title_full_unstemmed	Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India
title_sort	prevalence of y chromosome microdeletion in azoospermia factor subregions among infertile men from west bengal, india
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/189de64821084ac18bbbe10d3cde83fb
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Prevalence of Y chromosome microdeletion in azoospermia factor subregions among infertile men from West Bengal, India

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