The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences

Abstract Body mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differences and genetic predisposition to higher BMI. We...

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Autores principales:	Ida K. Karlsson, Margaret Gatz, Thalida Em Arpawong, Anna K. Dahl Aslan, Chandra A. Reynolds
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/189e7b941ca14b29b437a229f2eaf494
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spelling	oai:doaj.org-article:189e7b941ca14b29b437a229f2eaf4942021-12-02T18:17:41ZThe dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences10.1038/s41598-021-86667-42045-2322https://doaj.org/article/189e7b941ca14b29b437a229f2eaf4942021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86667-4https://doaj.org/toc/2045-2322Abstract Body mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differences and genetic predisposition to higher BMI. We used data from 23,892 individuals of European ancestry from the Health and Retirement Study, with longitudinal data on BMI and three established cognitive indices: mental status, episodic memory, and their sum, called total cognition. To investigate the dynamic relationship between BMI and cognitive abilities, we applied dual change score models of change from age 50 through 89, with a breakpoint at age 65 or 70. Models were further stratified by sex and genetic predisposition to higher BMI using tertiles of a polygenic score for BMI (PGSBMI). We demonstrated bidirectional effects between BMI and all three cognitive indices, with higher BMI contributing to steeper decline in cognitive abilities in both midlife and late-life, and higher cognitive abilities contributing to less decline in BMI in late-life. The effects of BMI on change in cognitive abilities were more evident in men compared to women, and among those in the lowest tertile of the PGSBMI compared to those in the highest tertile, while the effects of cognition on BMI were similar across groups. In conclusion, these findings highlight a reciprocal relationship between BMI and cognitive abilities, indicating that the negative effects of a higher BMI persist from midlife through late-life, and that weight-loss in late-life may be driven by cognitive decline.Ida K. KarlssonMargaret GatzThalida Em ArpawongAnna K. Dahl AslanChandra A. ReynoldsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ida K. Karlsson Margaret Gatz Thalida Em Arpawong Anna K. Dahl Aslan Chandra A. Reynolds The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
description	Abstract Body mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differences and genetic predisposition to higher BMI. We used data from 23,892 individuals of European ancestry from the Health and Retirement Study, with longitudinal data on BMI and three established cognitive indices: mental status, episodic memory, and their sum, called total cognition. To investigate the dynamic relationship between BMI and cognitive abilities, we applied dual change score models of change from age 50 through 89, with a breakpoint at age 65 or 70. Models were further stratified by sex and genetic predisposition to higher BMI using tertiles of a polygenic score for BMI (PGSBMI). We demonstrated bidirectional effects between BMI and all three cognitive indices, with higher BMI contributing to steeper decline in cognitive abilities in both midlife and late-life, and higher cognitive abilities contributing to less decline in BMI in late-life. The effects of BMI on change in cognitive abilities were more evident in men compared to women, and among those in the lowest tertile of the PGSBMI compared to those in the highest tertile, while the effects of cognition on BMI were similar across groups. In conclusion, these findings highlight a reciprocal relationship between BMI and cognitive abilities, indicating that the negative effects of a higher BMI persist from midlife through late-life, and that weight-loss in late-life may be driven by cognitive decline.
format	article
author	Ida K. Karlsson Margaret Gatz Thalida Em Arpawong Anna K. Dahl Aslan Chandra A. Reynolds
author_facet	Ida K. Karlsson Margaret Gatz Thalida Em Arpawong Anna K. Dahl Aslan Chandra A. Reynolds
author_sort	Ida K. Karlsson
title	The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
title_short	The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
title_full	The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
title_fullStr	The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
title_full_unstemmed	The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
title_sort	dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/189e7b941ca14b29b437a229f2eaf494
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The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences

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