Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investiga...

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Autores principales:	Irina Arkad'evna Bondar, Maksim Leonidovich Filipenko, Olesya Yur'evna Shabel'nikova, Ekaterina Alexeevna Sokolova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes mellitus pharmacogenomics insulin resistance sulfonylureas kcnj11 (rs5219) abcc8 (rs757110) Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/189f1a564a9e4b3e9653436ebe3fc7fb
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spelling	oai:doaj.org-article:189f1a564a9e4b3e9653436ebe3fc7fb2021-11-14T09:00:19ZLack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region2072-03512072-037810.14341/DM2015142-47https://doaj.org/article/189f1a564a9e4b3e9653436ebe3fc7fb2015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6697https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219) and ABCC8 (rs757110) was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia). Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, pIrina Arkad'evna BondarMaksim Leonidovich FilipenkoOlesya Yur'evna Shabel'nikovaEkaterina Alexeevna SokolovaEndocrinology Research Centrearticletype 2 diabetes mellituspharmacogenomicsinsulin resistancesulfonylureaskcnj11 (rs5219)abcc8 (rs757110)Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 42-47 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus pharmacogenomics insulin resistance sulfonylureas kcnj11 (rs5219) abcc8 (rs757110) Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus pharmacogenomics insulin resistance sulfonylureas kcnj11 (rs5219) abcc8 (rs757110) Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
description	Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219) and ABCC8 (rs757110) was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia). Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, p
format	article
author	Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova
author_facet	Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova
author_sort	Irina Arkad'evna Bondar
title	Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
title_short	Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
title_full	Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
title_fullStr	Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
title_full_unstemmed	Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
title_sort	lack of association between kcnj11 (rs5219) and abcc8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in novosibirsk region
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/189f1a564a9e4b3e9653436ebe3fc7fb
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Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

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