The role of directional interactions in the designability of generalized heteropolymers
Abstract Heteropolymers are important examples of self-assembling systems. However, in the design of artificial heteropolymers the control over the single chain self-assembling properties does not reach that of the natural bio-polymers, and in particular proteins. Here, we introduce a sufficiency cr...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/18aa4f50970942d0845915aecd7cea5e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:18aa4f50970942d0845915aecd7cea5e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:18aa4f50970942d0845915aecd7cea5e2021-12-02T12:30:18ZThe role of directional interactions in the designability of generalized heteropolymers10.1038/s41598-017-04720-72045-2322https://doaj.org/article/18aa4f50970942d0845915aecd7cea5e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04720-7https://doaj.org/toc/2045-2322Abstract Heteropolymers are important examples of self-assembling systems. However, in the design of artificial heteropolymers the control over the single chain self-assembling properties does not reach that of the natural bio-polymers, and in particular proteins. Here, we introduce a sufficiency criterion to identify polymers that can be designed to adopt a predetermined structure and show that it is fulfilled by polymers made of monomers interacting through directional (anisotropic) interactions. The criterion is based on the appearance of a particular peak in the radial distribution function, that we show being a universal feature of all designable heteropolymers, as it is present also in natural proteins. Our criterion can be used to engineer new self-assembling modular polymers that will open new avenues for applications in materials science.Chiara CardelliValentino BiancoLorenzo RovigattiFrancesca NerattiniLuca TubianaChristoph DellagoIvan ColuzzaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Chiara Cardelli Valentino Bianco Lorenzo Rovigatti Francesca Nerattini Luca Tubiana Christoph Dellago Ivan Coluzza The role of directional interactions in the designability of generalized heteropolymers |
| description |
Abstract Heteropolymers are important examples of self-assembling systems. However, in the design of artificial heteropolymers the control over the single chain self-assembling properties does not reach that of the natural bio-polymers, and in particular proteins. Here, we introduce a sufficiency criterion to identify polymers that can be designed to adopt a predetermined structure and show that it is fulfilled by polymers made of monomers interacting through directional (anisotropic) interactions. The criterion is based on the appearance of a particular peak in the radial distribution function, that we show being a universal feature of all designable heteropolymers, as it is present also in natural proteins. Our criterion can be used to engineer new self-assembling modular polymers that will open new avenues for applications in materials science. |
| format |
article |
| author |
Chiara Cardelli Valentino Bianco Lorenzo Rovigatti Francesca Nerattini Luca Tubiana Christoph Dellago Ivan Coluzza |
| author_facet |
Chiara Cardelli Valentino Bianco Lorenzo Rovigatti Francesca Nerattini Luca Tubiana Christoph Dellago Ivan Coluzza |
| author_sort |
Chiara Cardelli |
| title |
The role of directional interactions in the designability of generalized heteropolymers |
| title_short |
The role of directional interactions in the designability of generalized heteropolymers |
| title_full |
The role of directional interactions in the designability of generalized heteropolymers |
| title_fullStr |
The role of directional interactions in the designability of generalized heteropolymers |
| title_full_unstemmed |
The role of directional interactions in the designability of generalized heteropolymers |
| title_sort |
role of directional interactions in the designability of generalized heteropolymers |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/18aa4f50970942d0845915aecd7cea5e |
| work_keys_str_mv |
AT chiaracardelli theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT valentinobianco theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT lorenzorovigatti theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT francescanerattini theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT lucatubiana theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT christophdellago theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT ivancoluzza theroleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT chiaracardelli roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT valentinobianco roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT lorenzorovigatti roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT francescanerattini roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT lucatubiana roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT christophdellago roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers AT ivancoluzza roleofdirectionalinteractionsinthedesignabilityofgeneralizedheteropolymers |
| _version_ |
1718394382189592576 |