Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays

In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i...

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Autores principales:	Lilian Mussi, André Rolim Baby, Flavio Bueno Camargo Junior, Giovana Padovani, Bianca da Silva Sufi, Wagner Vidal Magalhães
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acne xylitol caprylic acid propanediol porphyrin 5-alpha reductase Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/18ac208429184b9b89ced7395dc33c53
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spelling	oai:doaj.org-article:18ac208429184b9b89ced7395dc33c532021-11-11T18:39:08ZPropanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays10.3390/molecules262167041420-3049https://doaj.org/article/18ac208429184b9b89ced7395dc33c532021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6704https://doaj.org/toc/1420-3049In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i>. Despite this, we investigated the existence of a synergistic effect among xylitol, caprylic acid and propanediol as a mixture of compounds representing a single topical active ingredient that could benefit the treatment against acne. In vitro and in vivo assays were performed to challenge and to prove the efficacy of propanediol, xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged against <i>C. acnes</i> (formerly <i>Propionibacterium acnes</i>) and <i>Staphylococcus aureus</i>, resulting in concentrations of 0.125% and 0.25%, respectively, and it also developed antimicrobial activity against <i>C. acnes</i> (time-kill test). PXCA was able to reduce the 5-alpha reductase expression in 24% (<i>p</i> < 0.01) in comparison with the testosterone group. By the end of 28 days of treatment, the compound reduced the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in participants. According to the dermatologist evaluation, PXCA improved the skin’s general appearance, acne presence and size.Lilian MussiAndré Rolim BabyFlavio Bueno Camargo JuniorGiovana PadovaniBianca da Silva SufiWagner Vidal MagalhãesMDPI AGarticleacnexylitolcaprylic acidpropanediolporphyrin5-alpha reductaseOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6704, p 6704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acne xylitol caprylic acid propanediol porphyrin 5-alpha reductase Organic chemistry QD241-441
spellingShingle	acne xylitol caprylic acid propanediol porphyrin 5-alpha reductase Organic chemistry QD241-441 Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
description	In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i>. Despite this, we investigated the existence of a synergistic effect among xylitol, caprylic acid and propanediol as a mixture of compounds representing a single topical active ingredient that could benefit the treatment against acne. In vitro and in vivo assays were performed to challenge and to prove the efficacy of propanediol, xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged against <i>C. acnes</i> (formerly <i>Propionibacterium acnes</i>) and <i>Staphylococcus aureus</i>, resulting in concentrations of 0.125% and 0.25%, respectively, and it also developed antimicrobial activity against <i>C. acnes</i> (time-kill test). PXCA was able to reduce the 5-alpha reductase expression in 24% (<i>p</i> < 0.01) in comparison with the testosterone group. By the end of 28 days of treatment, the compound reduced the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in participants. According to the dermatologist evaluation, PXCA improved the skin’s general appearance, acne presence and size.
format	article
author	Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães
author_facet	Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães
author_sort	Lilian Mussi
title	Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
title_short	Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
title_full	Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
title_fullStr	Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
title_full_unstemmed	Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
title_sort	propanediol (and) caprylic acid (and) xylitol as a new single topical active ingredient against acne: in vitro and in vivo efficacy assays
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/18ac208429184b9b89ced7395dc33c53
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Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays

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