Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas

Background/Aims We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC). Methods A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015. Results The most common location...

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Autores principales:	Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	esophageal carcinoma synchronous cancer prognosis multiple lesions definitive therapy Medicine R
Acceso en línea:	https://doaj.org/article/18ae85bcab3f4077b84426516e902937
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spelling	oai:doaj.org-article:18ae85bcab3f4077b84426516e9029372021-11-08T00:59:06ZClinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas1226-33032005-664810.3904/kjim.2017.280https://doaj.org/article/18ae85bcab3f4077b84426516e9029372021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2017-280.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Background/Aims We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC). Methods A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015. Results The most common locations of SMPESCC were mid- and lower thoracic segments (n = 208, 84.9%). The 1-, 2-, and 3-year overall survival rates were 53.8%, 30.8%, and 15.4%, respectively; the median survival time (MST) was 12.5 months. With definitive radiotherapy and surgery, respectively, the MST of stage I/II patients were 34.2 and 26.7 months, of stage III patients were 8.3 and 13.2 months (p = 0.163), and of stage IV patients were and 8 and 12.6 months (p = 0.379). Clinical stage, family history of cancer, and Karnofsky performance status were independent prognostic factors for the whole cohort by Cox multivariate regression analysis (hazard ratio [HR] = 0.859, p < 0.001; HR = 0.579, p = 0.032; and HR = 0.586, p = 0.013). Conclusions Although the prognosis of SMPESCC is poor, stage I/II patients can achieve long-term survival with aggressive treatment, especially those with a Karnofsky performance score 90 or higher and who have no family history of cancer. Definitive radiotherapy could achieve a similar survival rate to definitive surgery at different clinical stages.Zhiqin ChenSihan LiZheng HeGuang LiThe Korean Association of Internal Medicinearticleesophageal carcinomasynchronous cancerprognosismultiple lesionsdefinitive therapyMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1356-1364 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal carcinoma synchronous cancer prognosis multiple lesions definitive therapy Medicine R
spellingShingle	esophageal carcinoma synchronous cancer prognosis multiple lesions definitive therapy Medicine R Zhiqin Chen Sihan Li Zheng He Guang Li Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
description	Background/Aims We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC). Methods A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015. Results The most common locations of SMPESCC were mid- and lower thoracic segments (n = 208, 84.9%). The 1-, 2-, and 3-year overall survival rates were 53.8%, 30.8%, and 15.4%, respectively; the median survival time (MST) was 12.5 months. With definitive radiotherapy and surgery, respectively, the MST of stage I/II patients were 34.2 and 26.7 months, of stage III patients were 8.3 and 13.2 months (p = 0.163), and of stage IV patients were and 8 and 12.6 months (p = 0.379). Clinical stage, family history of cancer, and Karnofsky performance status were independent prognostic factors for the whole cohort by Cox multivariate regression analysis (hazard ratio [HR] = 0.859, p < 0.001; HR = 0.579, p = 0.032; and HR = 0.586, p = 0.013). Conclusions Although the prognosis of SMPESCC is poor, stage I/II patients can achieve long-term survival with aggressive treatment, especially those with a Karnofsky performance score 90 or higher and who have no family history of cancer. Definitive radiotherapy could achieve a similar survival rate to definitive surgery at different clinical stages.
format	article
author	Zhiqin Chen Sihan Li Zheng He Guang Li
author_facet	Zhiqin Chen Sihan Li Zheng He Guang Li
author_sort	Zhiqin Chen
title	Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
title_short	Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
title_full	Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
title_fullStr	Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
title_full_unstemmed	Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
title_sort	clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/18ae85bcab3f4077b84426516e902937
work_keys_str_mv	AT zhiqinchen clinicalanalysisof117caseswithsynchronousmultipleprimaryesophagealsquamouscellcarcinomas AT sihanli clinicalanalysisof117caseswithsynchronousmultipleprimaryesophagealsquamouscellcarcinomas AT zhenghe clinicalanalysisof117caseswithsynchronousmultipleprimaryesophagealsquamouscellcarcinomas AT guangli clinicalanalysisof117caseswithsynchronousmultipleprimaryesophagealsquamouscellcarcinomas
_version_	1718443260139012096

Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas

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