G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression

The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcrip...

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Autores principales:	Xi Zhang, Danni Peng, Yuanxin Xi, Chao Yuan, Cari A. Sagum, Brianna J. Klein, Kaori Tanaka, Hong Wen, Tatiana G. Kutateladze, Wei Li, Mark T. Bedford, Xiaobing Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18b3102f959446d6a42a196df7da8f6d
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spelling	oai:doaj.org-article:18b3102f959446d6a42a196df7da8f6d2021-12-02T17:33:22ZG9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression10.1038/ncomms108102041-1723https://doaj.org/article/18b3102f959446d6a42a196df7da8f6d2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10810https://doaj.org/toc/2041-1723The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcription.Xi ZhangDanni PengYuanxin XiChao YuanCari A. SagumBrianna J. KleinKaori TanakaHong WenTatiana G. KutateladzeWei LiMark T. BedfordXiaobing ShiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xi Zhang Danni Peng Yuanxin Xi Chao Yuan Cari A. Sagum Brianna J. Klein Kaori Tanaka Hong Wen Tatiana G. Kutateladze Wei Li Mark T. Bedford Xiaobing Shi G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
description	The histone methyltransferase G9a methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. Here, Zhang et al. show that methylation of ERα by G9a recruits the PHF20/MOF complex that deposits histone H4K16 acetylation promoting active transcription.
format	article
author	Xi Zhang Danni Peng Yuanxin Xi Chao Yuan Cari A. Sagum Brianna J. Klein Kaori Tanaka Hong Wen Tatiana G. Kutateladze Wei Li Mark T. Bedford Xiaobing Shi
author_facet	Xi Zhang Danni Peng Yuanxin Xi Chao Yuan Cari A. Sagum Brianna J. Klein Kaori Tanaka Hong Wen Tatiana G. Kutateladze Wei Li Mark T. Bedford Xiaobing Shi
author_sort	Xi Zhang
title	G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
title_short	G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
title_full	G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
title_fullStr	G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
title_full_unstemmed	G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
title_sort	g9a-mediated methylation of erα links the phf20/mof histone acetyltransferase complex to hormonal gene expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/18b3102f959446d6a42a196df7da8f6d
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G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression

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