Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players

Código QR

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players

Familial hypercholesterolemia (FH) is associated with low-grade systemic inflammation, a key driver of premature atherosclerosis. We investigated the effects of inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) function on inflammatory state, endothelial dysfunction and cardiovascular...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervás, Juan F. Ascaso, Laura Piqueras, José T. Real, Maria-Jesus Sanz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Familial hypercholesterolemia PCSK9 Alirocumab Systemic inflammation Endothelial dysfunction Atherosclerosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/18b9bb9d7ffb44ad935d98f1e616d8cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

A spotlight on alirocumab in high cardiovascular risk patients with type 2 diabetes and mixed dyslipidemia: a review on the emerging data
por: Rana K, et al.
Publicado: (2019)

Safety and Tolerability of PCSK9 Inhibitors: Current Insights
por: Kosmas CE, et al.
Publicado: (2020)

Emerging Non-statin Treatment Options for Lowering Low-Density Lipoprotein Cholesterol
por: Chandni Bardolia, et al.
Publicado: (2021)

Nuevas piezas en el puzzle de la aterogénesis
por: de la Maza C,M Pía, et al.
Publicado: (1999)

Acaudina molpadioides mediates lipid uptake by suppressing PCSK9 transcription and increasing LDL receptor in human liver cells
por: Allicia Jack, et al.
Publicado: (2021)

Effects of immunisation against PCSK9 in mice bearing melanoma
por: Amir Abbas Momtazi-Borojeni, et al.
Publicado: (2019)

PCSK9 Gene Polymorphisms Associated With the Risk of Myocardial Infarction in Iranian Patients
por: Farshad Namordizadeh, et al.
Publicado: (2021)

Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential
por: Kosmas CE, et al.
Publicado: (2020)

A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese Subjects
por: Liu C, et al.
Publicado: (2019)

Frequency of Common Variants in Genes Involved in Lipid-Lowering Response to Statins in Chilean Subjects with Hypercholesterolemia
por: Rosales,Alexy, et al.
Publicado: (2011)

Selected spices and their combination modulate hypercholesterolemia-induced oxidative stress in experimental rats
por: Otunola,Gloria A, et al.
Publicado: (2014)

Is PCSK9 Associated with Plasma Lipid Levels in a Sub-Saharan African Population of Patients with Obesity and Type 2 Diabetes?
por: Mba CM, et al.
Publicado: (2019)

Benefit–risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients
por: Chamberlin KW, et al.
Publicado: (2015)

Apolipoprotein B gene mutation related to familial hypercholesterolemia in an Iranian population: With or without hypothyroidism
por: Golnaz Vaseghi, et al.
Publicado: (2021)

Grculation of microparticles of lymphocytic origin at critical ischemia of the lower extremities
por: Y. S. Vinnik, et al.
Publicado: (2020)

Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
por: Jia Peng, et al.
Publicado: (2021)

Risk Factors of Hypercholesterolemia on Obese Pre-elderly Population in Rejosari Sub-village Gunung Kidul Yogyakarta
por: Desto Arisandi, et al.
Publicado: (2016)

Hypercholesterolemia and tissue-specific differential mRNA expression of type-1 5'-iodothyronine deiodinase under different selenium status in rats
por: DHINGRA,SANJIV, et al.
Publicado: (2006)

Data mining: traditional spring festival associated with hypercholesterolemia
por: Danchen Wang, et al.
Publicado: (2021)

NcRNAs in Vascular and Valvular Intercellular Communication
por: Benedikt Bartsch, et al.
Publicado: (2021)

Facile preparation of Fe2O3 nanoparticles mediated by Centaurea alba extract and assessment of the anti-atherosclerotic properties
por: Jian Xiu, et al.
Publicado: (2022)

Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice
por: Junying Xiao, et al.
Publicado: (2021)

A Systematic Review and Meta-Analysis of Therapeutic Efficacy and Safety of Alirocumab and Evolocumab on Familial Hypercholesterolemia
por: Xiaoyue Ge, et al.
Publicado: (2021)

Cell adhesion molecules and exercise
por: Koh Y, et al.
Publicado: (2018)

Daño endotelial y activación del sistema hemostático asociado al uso crónico de cocaína: estudios ex vivo e in vitro
por: Pereira,Jaime, et al.
Publicado: (2010)

Formulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study
por: Shrestha SC, et al.
Publicado: (2021)

Niveles aumentados de estrés oxidativo se asocian a disfunción endotelial periférica y respuesta vascular pulmonar disminuida frente a vasodilatadores en pacientes con hipertensión pulmonar
por: Gabrielli,Luigi, et al.
Publicado: (2010)

Endothelial cell oxidative stress and signal transduction
por: FONCEA,ROCIO, et al.
Publicado: (2000)

Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
por: Vladislav Biel, et al.
Publicado: (2021)

Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
por: V. G. Banzaraksheev
Publicado: (2016)

Myocardial fibrosis assessed by magnetic resonance imaging in asymptomatic heterozygous familial hypercholesterolemia: the cholcoeur study
por: Antonio Gallo, et al.
Publicado: (2021)

Respuestas metabólicas inducidas por ejercicio físico de alta intensidad en mujeres sedentarias con glicemia basal alterada e hipercolesterolemia
por: Álvarez L.,Cristián, et al.
Publicado: (2013)

Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey
por: Natalya Alexandrovna Gavrilova, et al.
Publicado: (2011)

Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
por: Ravichandran Jayasuriya, et al.
Publicado: (2022)

The Glomerular Endothelium Restricts Albumin Filtration
por: Barbara J. Ballermann, et al.
Publicado: (2021)

Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of <italic toggle="no">ApoE</italic><sup>−/−</sup> Mice
por: Yuxiang Zhou, et al.
Publicado: (2021)

Proteinuria-Lowering Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Chronic Kidney Disease Patients: A Real-World Multicentric Study
por: Patricia Muñoz Ramos, et al.
Publicado: (2021)

El tratamiento con atorvastatina reduce la actividad de xantina-oxidasa unida al endotelio en pacientes con insuficiencia cardíaca crónica: ¿Un posible nuevo efecto pleiotrópico?
por: Alcaíno,Hernán, et al.
Publicado: (2009)

Dynamics of Matrix Metalloproteinases in Local Cold Injury
por: M. I. Mikhailichenko, et al.
Publicado: (2019)

Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Thi Thuy Uyen Nguyen, et al.
Publicado: (2021)