Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players
Familial hypercholesterolemia (FH) is associated with low-grade systemic inflammation, a key driver of premature atherosclerosis. We investigated the effects of inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) function on inflammatory state, endothelial dysfunction and cardiovascular...
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Main Authors: | Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervás, Juan F. Ascaso, Laura Piqueras, José T. Real, Maria-Jesus Sanz |
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Format: | article |
Language: | EN |
Published: |
Elsevier
2022
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Online Access: | https://doaj.org/article/18b9bb9d7ffb44ad935d98f1e616d8cd |
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