Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

Droplet-based single-cell RNA-seq is a powerful tool for cellular heterogeneity profiling in disease but is limited by instrumentation required. Here the authors develop a 3D printed microfluidic platform for massive parallel sequencing of rheumatoid arthritis tissues.

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Autores principales:	William Stephenson, Laura T. Donlin, Andrew Butler, Cristina Rozo, Bernadette Bracken, Ali Rashidfarrokhi, Susan M. Goodman, Lionel B. Ivashkiv, Vivian P. Bykerk, Dana E. Orange, Robert B. Darnell, Harold P. Swerdlow, Rahul Satija
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18bf9f63e8264f93bad6159c684d6840
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spelling	oai:doaj.org-article:18bf9f63e8264f93bad6159c684d68402021-12-02T16:49:19ZSingle-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation10.1038/s41467-017-02659-x2041-1723https://doaj.org/article/18bf9f63e8264f93bad6159c684d68402018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02659-xhttps://doaj.org/toc/2041-1723Droplet-based single-cell RNA-seq is a powerful tool for cellular heterogeneity profiling in disease but is limited by instrumentation required. Here the authors develop a 3D printed microfluidic platform for massive parallel sequencing of rheumatoid arthritis tissues.William StephensonLaura T. DonlinAndrew ButlerCristina RozoBernadette BrackenAli RashidfarrokhiSusan M. GoodmanLionel B. IvashkivVivian P. BykerkDana E. OrangeRobert B. DarnellHarold P. SwerdlowRahul SatijaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William Stephenson Laura T. Donlin Andrew Butler Cristina Rozo Bernadette Bracken Ali Rashidfarrokhi Susan M. Goodman Lionel B. Ivashkiv Vivian P. Bykerk Dana E. Orange Robert B. Darnell Harold P. Swerdlow Rahul Satija Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
description	Droplet-based single-cell RNA-seq is a powerful tool for cellular heterogeneity profiling in disease but is limited by instrumentation required. Here the authors develop a 3D printed microfluidic platform for massive parallel sequencing of rheumatoid arthritis tissues.
format	article
author	William Stephenson Laura T. Donlin Andrew Butler Cristina Rozo Bernadette Bracken Ali Rashidfarrokhi Susan M. Goodman Lionel B. Ivashkiv Vivian P. Bykerk Dana E. Orange Robert B. Darnell Harold P. Swerdlow Rahul Satija
author_facet	William Stephenson Laura T. Donlin Andrew Butler Cristina Rozo Bernadette Bracken Ali Rashidfarrokhi Susan M. Goodman Lionel B. Ivashkiv Vivian P. Bykerk Dana E. Orange Robert B. Darnell Harold P. Swerdlow Rahul Satija
author_sort	William Stephenson
title	Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
title_short	Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
title_full	Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
title_fullStr	Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
title_full_unstemmed	Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
title_sort	single-cell rna-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/18bf9f63e8264f93bad6159c684d6840
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Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

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