Fertility problems in males carrying an inversion of chromosome 10

Chromosomal inversion is closely related to male infertility. Inversion carriers may produce abnormal gametes, which may lead to partial duplication/deletion of the embryonic chromosome and result in spontaneous abortion, a fetus with multiple anomalies, or birth of a malformed child. Genetic counse...

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Autores principales:	Zhang Xinyue, Shi Qingyang, Liu Yanhong, Jiang Yuting, Yang Xiao, Liu Ruizhi, Zhang Hongguo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	chromosome 10 inversion male infertility genetic counselling Medicine R
Acceso en línea:	https://doaj.org/article/18c27e3e1dcf4a0887d4fd4aecf0ce1a
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spelling	oai:doaj.org-article:18c27e3e1dcf4a0887d4fd4aecf0ce1a2021-12-05T14:10:54ZFertility problems in males carrying an inversion of chromosome 102391-546310.1515/med-2021-0240https://doaj.org/article/18c27e3e1dcf4a0887d4fd4aecf0ce1a2021-02-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0240https://doaj.org/toc/2391-5463Chromosomal inversion is closely related to male infertility. Inversion carriers may produce abnormal gametes, which may lead to partial duplication/deletion of the embryonic chromosome and result in spontaneous abortion, a fetus with multiple anomalies, or birth of a malformed child. Genetic counselling remains challenging for these carriers in clinical practice. We report two male carriers with inversion of chromosome 10 and review 26 reported cases. In the first case, 46,XX,inv(10)(p13q22) of the fetal chromosome was found in prenatal diagnosis; this was inherited from the paternal side with 46XY,inv(10)(p13q22). Another case was a male carrier with inv(10)(q21.2q22.1). There have been 25 (89.3%) cases of pericentric inversion and three (10.7%) cases of paracentric inversion involving chromosome 10. Of 28 cases, nine were associated with pregestational infertility of the couples, while the other 19 cases were associated with gestational infertility of the couples or normozoospermia. The breakpoints at 10p15, 10p11, 10q11, and 10q21 were associated with pregestational infertility of the couples. The breakpoints at 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, and 10q26 were related to gestational infertility of the couples or normozoospermia. Although there is a high risk of infertility or recurrent miscarriages, carriers with inversion of chromosome 10 might produce healthy offspring. Natural pregnancy can be used as a choice for inversion carriers with recurrent spontaneous abortion.Zhang XinyueShi QingyangLiu YanhongJiang YutingYang XiaoLiu RuizhiZhang HongguoDe Gruyterarticlechromosome 10inversionmale infertilitygenetic counsellingMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 316-321 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chromosome 10 inversion male infertility genetic counselling Medicine R
spellingShingle	chromosome 10 inversion male infertility genetic counselling Medicine R Zhang Xinyue Shi Qingyang Liu Yanhong Jiang Yuting Yang Xiao Liu Ruizhi Zhang Hongguo Fertility problems in males carrying an inversion of chromosome 10
description	Chromosomal inversion is closely related to male infertility. Inversion carriers may produce abnormal gametes, which may lead to partial duplication/deletion of the embryonic chromosome and result in spontaneous abortion, a fetus with multiple anomalies, or birth of a malformed child. Genetic counselling remains challenging for these carriers in clinical practice. We report two male carriers with inversion of chromosome 10 and review 26 reported cases. In the first case, 46,XX,inv(10)(p13q22) of the fetal chromosome was found in prenatal diagnosis; this was inherited from the paternal side with 46XY,inv(10)(p13q22). Another case was a male carrier with inv(10)(q21.2q22.1). There have been 25 (89.3%) cases of pericentric inversion and three (10.7%) cases of paracentric inversion involving chromosome 10. Of 28 cases, nine were associated with pregestational infertility of the couples, while the other 19 cases were associated with gestational infertility of the couples or normozoospermia. The breakpoints at 10p15, 10p11, 10q11, and 10q21 were associated with pregestational infertility of the couples. The breakpoints at 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, and 10q26 were related to gestational infertility of the couples or normozoospermia. Although there is a high risk of infertility or recurrent miscarriages, carriers with inversion of chromosome 10 might produce healthy offspring. Natural pregnancy can be used as a choice for inversion carriers with recurrent spontaneous abortion.
format	article
author	Zhang Xinyue Shi Qingyang Liu Yanhong Jiang Yuting Yang Xiao Liu Ruizhi Zhang Hongguo
author_facet	Zhang Xinyue Shi Qingyang Liu Yanhong Jiang Yuting Yang Xiao Liu Ruizhi Zhang Hongguo
author_sort	Zhang Xinyue
title	Fertility problems in males carrying an inversion of chromosome 10
title_short	Fertility problems in males carrying an inversion of chromosome 10
title_full	Fertility problems in males carrying an inversion of chromosome 10
title_fullStr	Fertility problems in males carrying an inversion of chromosome 10
title_full_unstemmed	Fertility problems in males carrying an inversion of chromosome 10
title_sort	fertility problems in males carrying an inversion of chromosome 10
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/18c27e3e1dcf4a0887d4fd4aecf0ce1a
work_keys_str_mv	AT zhangxinyue fertilityproblemsinmalescarryinganinversionofchromosome10 AT shiqingyang fertilityproblemsinmalescarryinganinversionofchromosome10 AT liuyanhong fertilityproblemsinmalescarryinganinversionofchromosome10 AT jiangyuting fertilityproblemsinmalescarryinganinversionofchromosome10 AT yangxiao fertilityproblemsinmalescarryinganinversionofchromosome10 AT liuruizhi fertilityproblemsinmalescarryinganinversionofchromosome10 AT zhanghongguo fertilityproblemsinmalescarryinganinversionofchromosome10
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Fertility problems in males carrying an inversion of chromosome 10

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