Sites of high local frustration in DNA origami
Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.
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Nature Portfolio
2019
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oai:doaj.org-article:18c3fb80b55445e2b7a1c1e064f84fa52021-12-02T16:58:07ZSites of high local frustration in DNA origami10.1038/s41467-019-09002-62041-1723https://doaj.org/article/18c3fb80b55445e2b7a1c1e064f84fa52019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09002-6https://doaj.org/toc/2041-1723Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.Richard KosinskiAnn MukhortavaWolfgang PfeiferAndrea CandelliPhilipp RauchBarbara SaccàNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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Science Q Richard Kosinski Ann Mukhortava Wolfgang Pfeifer Andrea Candelli Philipp Rauch Barbara Saccà Sites of high local frustration in DNA origami |
description |
Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape. |
format |
article |
author |
Richard Kosinski Ann Mukhortava Wolfgang Pfeifer Andrea Candelli Philipp Rauch Barbara Saccà |
author_facet |
Richard Kosinski Ann Mukhortava Wolfgang Pfeifer Andrea Candelli Philipp Rauch Barbara Saccà |
author_sort |
Richard Kosinski |
title |
Sites of high local frustration in DNA origami |
title_short |
Sites of high local frustration in DNA origami |
title_full |
Sites of high local frustration in DNA origami |
title_fullStr |
Sites of high local frustration in DNA origami |
title_full_unstemmed |
Sites of high local frustration in DNA origami |
title_sort |
sites of high local frustration in dna origami |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/18c3fb80b55445e2b7a1c1e064f84fa5 |
work_keys_str_mv |
AT richardkosinski sitesofhighlocalfrustrationindnaorigami AT annmukhortava sitesofhighlocalfrustrationindnaorigami AT wolfgangpfeifer sitesofhighlocalfrustrationindnaorigami AT andreacandelli sitesofhighlocalfrustrationindnaorigami AT philipprauch sitesofhighlocalfrustrationindnaorigami AT barbarasacca sitesofhighlocalfrustrationindnaorigami |
_version_ |
1718382373674942464 |