Sites of high local frustration in DNA origami

Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.

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Autores principales: Richard Kosinski, Ann Mukhortava, Wolfgang Pfeifer, Andrea Candelli, Philipp Rauch, Barbara Saccà
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/18c3fb80b55445e2b7a1c1e064f84fa5
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spelling oai:doaj.org-article:18c3fb80b55445e2b7a1c1e064f84fa52021-12-02T16:58:07ZSites of high local frustration in DNA origami10.1038/s41467-019-09002-62041-1723https://doaj.org/article/18c3fb80b55445e2b7a1c1e064f84fa52019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09002-6https://doaj.org/toc/2041-1723Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.Richard KosinskiAnn MukhortavaWolfgang PfeiferAndrea CandelliPhilipp RauchBarbara SaccàNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Richard Kosinski
Ann Mukhortava
Wolfgang Pfeifer
Andrea Candelli
Philipp Rauch
Barbara Saccà
Sites of high local frustration in DNA origami
description Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.
format article
author Richard Kosinski
Ann Mukhortava
Wolfgang Pfeifer
Andrea Candelli
Philipp Rauch
Barbara Saccà
author_facet Richard Kosinski
Ann Mukhortava
Wolfgang Pfeifer
Andrea Candelli
Philipp Rauch
Barbara Saccà
author_sort Richard Kosinski
title Sites of high local frustration in DNA origami
title_short Sites of high local frustration in DNA origami
title_full Sites of high local frustration in DNA origami
title_fullStr Sites of high local frustration in DNA origami
title_full_unstemmed Sites of high local frustration in DNA origami
title_sort sites of high local frustration in dna origami
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/18c3fb80b55445e2b7a1c1e064f84fa5
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AT annmukhortava sitesofhighlocalfrustrationindnaorigami
AT wolfgangpfeifer sitesofhighlocalfrustrationindnaorigami
AT andreacandelli sitesofhighlocalfrustrationindnaorigami
AT philipprauch sitesofhighlocalfrustrationindnaorigami
AT barbarasacca sitesofhighlocalfrustrationindnaorigami
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